{"id":"W1968812829","doi":"10.3390/md11041087","title":"6″-Debromohamacanthin A, a Bis (Indole) Alkaloid, Inhibits Angiogenesis by Targeting the VEGFR2-Mediated PI3K/AKT/mTOR Signaling Pathways","year":2013,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Angiogenesis; PI3K/AKT/mTOR pathway; Cell biology; Protein kinase B; Endothelial stem cell; Vascular endothelial growth factor; Biology; Sprouting angiogenesis; Signal transduction; Vascular endothelial growth factor A; Chemistry; Cancer research; Neovascularization; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000414982,0.000230541,0.0001068907,0.0001201892,0.0000644172,0.00009589754,0.00008202876,0.0001180718,0.0005972468],"category_scores_gemma":[0.00003469412,0.00004879004,0.0001508883,0.00006024662,0.00007305769,0.00007860261,0.00007327119,0.0002195888,0.00009191103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008740359,"about_ca_system_score_gemma":0.00009970596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004769931,"about_ca_topic_score_gemma":0.001030217,"domain_scores_codex":[0.9999717,0.000004672774,0.000003360346,0.000005073758,0.000007421394,0.000007717412],"domain_scores_gemma":[0.9999841,0.000002798897,0.000004508353,0.000001346569,0.000002207191,0.000004962377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000103215,0.00003107839,0.0001613233,0.00006328661,0.000006248803,0.00003743465,0.000004221447,0.0000454854,0.9962736,0.00003772012,0.00003785862,0.003198444],"study_design_scores_gemma":[0.00007304134,0.001057198,0.01518216,0.00001225521,0.0000358609,0.0003946837,0.00002437431,0.001335093,0.9766896,0.0000421454,0.005147008,0.000006622829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902924,0.006333238,0.001161112,0.00007520802,0.00004533974,0.00002805878,0.0001904184,0.0000451294,0.001829137],"genre_scores_gemma":[0.9950575,0.002512428,0.001012415,0.00004506353,0.0000131937,0.00002425467,0.0001803329,0.000003007605,0.001151895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005972468,"threshold_uncertainty_score":0.001997948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004580811651545614,"score_gpt":0.1887440972638476,"score_spread":0.184163285612302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}