{"id":"W1968814333","doi":"10.1074/jbc.m111.310409","title":"Mutation of Glu521 or Glu535 in Cytoplasmic Loop 5 Causes Differential Misfolding in Multiple Domains of Multidrug and Organic Anion Transporter MRP1 (ABCC1)","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"ABCC1; Transporter; Cytoplasm; Organic anion transporter 1; ATP-binding cassette transporter; Organic cation transport proteins; Chemistry; Loop (graph theory); Mutation; Multiple drug resistance; Differential (mechanical device); Biology; Biochemistry; Cell biology; Gene; Physics; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961,0.000506119,0.0002466073,0.0001308287,0.0001762324,0.0002842213,0.0002756329,0.0004661386,0.001380855],"category_scores_gemma":[0.0002361725,0.0001923362,0.0004085113,0.0001648242,0.0003613352,0.0001975601,0.0002517161,0.0004102372,0.0006466259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004547609,"about_ca_system_score_gemma":0.0001886603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001283426,"about_ca_topic_score_gemma":0.0009541902,"domain_scores_codex":[0.9997389,0.00005286209,0.00006385623,0.00004606077,0.00004687535,0.00005147117],"domain_scores_gemma":[0.9997653,0.00004576106,0.00009392336,0.00002815998,0.00001234897,0.00005447118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004455725,0.0001127052,0.0006989387,0.0000358149,0.00002470548,0.0005485493,0.00002622414,0.0003552313,0.9963426,0.0001896164,0.00007143902,0.001148642],"study_design_scores_gemma":[0.0001066185,0.001219714,0.01205953,0.00001912072,0.00007908046,0.002292698,0.0001026475,0.003278796,0.9789239,0.0001029557,0.001788664,0.00002624598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987742,0.0001455474,0.0004926157,0.00004206509,0.00001734712,0.000009522568,0.0001581026,0.00002268772,0.0003379532],"genre_scores_gemma":[0.9984268,0.0001074934,0.0005331616,0.00005295367,0.000004920623,0.00000949015,0.0002692234,0.00001630224,0.0005797715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001380855,"threshold_uncertainty_score":0.00461942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552001170064488,"score_gpt":0.2572649714820626,"score_spread":0.2317449597814177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}