{"id":"W1968848278","doi":"10.1371/journal.pone.0049562","title":"Autologous HIV-1 Clade-B Nef Peptides Elicit Increased Frequency, Breadth and Function of CD8+ T-Cells Compared to Consensus Peptides","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada); Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"CD8; Flow cytometry; Biology; Consensus sequence; Immune system; Immunology; Antibody; Cytotoxic T cell; Peptide sequence; Virology; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415653,0.0002269802,0.0002067165,0.00008137036,0.00009731398,0.0001360472,0.00007095611,0.0003514937,0.002551334],"category_scores_gemma":[0.000225872,0.00008431061,0.00007175912,0.00004094488,0.00009765579,0.0001156534,0.0001121563,0.0003096643,0.0003090208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006860516,"about_ca_system_score_gemma":0.00005134958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001363262,"about_ca_topic_score_gemma":0.0001275141,"domain_scores_codex":[0.9999167,0.00001544441,0.000007957153,0.000032868,0.00001087954,0.00001616966],"domain_scores_gemma":[0.999896,0.00003531645,0.00001573281,0.00001253086,0.00001114257,0.0000293318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007491377,0.0001564163,0.004304413,0.00005989693,0.000006102952,0.0001199253,0.00007850667,0.00006716773,0.98882,0.00001518233,0.00004437468,0.005578902],"study_design_scores_gemma":[0.0004770107,0.01403124,0.1977402,0.00004235564,0.00008327862,0.01142359,0.0004118805,0.003009859,0.7698006,0.0001957465,0.002763825,0.0000203936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999424,0.0001062184,0.0001892497,0.000007765737,0.000002660683,0.00001105867,0.00002506438,0.000007479583,0.0002265822],"genre_scores_gemma":[0.9990687,0.00004867706,0.0003845032,0.00002561742,0.000006368068,0.00001209846,0.00005098481,0.000003351338,0.0003997276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002551334,"threshold_uncertainty_score":0.008535087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837366814174431,"score_gpt":0.2427586633817378,"score_spread":0.2043849952399935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}