{"id":"W1968872063","doi":"10.1006/viro.2000.0253","title":"The Effect of Mutant Peptide Cofactors on Adenovirus Protease Activity and Virus Infection","year":2000,"lang":"en","type":"article","venue":"Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Medical Research Council","keywords":"Peptide; Biology; Mutant; Protease; Biochemistry; Peptide sequence; In vitro; Cofactor; Cysteine; Enzyme; Virus; Molecular biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004190273,0.00014033,0.0001538406,0.00003844428,0.0001409589,0.00001064796,0.000109675,0.0001582823,0.00008745102],"category_scores_gemma":[0.00009229074,0.00009534887,0.00006042925,0.00006794511,0.0002707804,0.000002656944,0.00004112102,0.0001683899,0.00002732852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001302693,"about_ca_system_score_gemma":0.000032054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002381913,"about_ca_topic_score_gemma":0.0005408817,"domain_scores_codex":[0.9987715,0.0004709464,0.0001262969,0.0002696343,0.0001139855,0.000247652],"domain_scores_gemma":[0.9994316,0.0000919236,0.00005745517,0.0003360999,0.0000180742,0.00006487548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01160525,0.00004001855,0.003109905,0.000009374496,0.0000529634,0.000003806189,0.00001050493,0.00007269969,0.9212258,0.000002531641,0.00005976312,0.06380738],"study_design_scores_gemma":[0.0007733715,0.01578162,0.0188466,0.000002856755,0.00001138768,0.00001522437,8.168738e-7,0.00005124114,0.9566114,0.00001827027,0.007798563,0.00008863166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998799,0.0002238115,0.00001024837,0.0001109171,0.00004432912,0.0004219067,0.00001550289,0.00001007731,0.0003641972],"genre_scores_gemma":[0.99871,0.0008101527,0.000002002329,0.00007855955,0.00007431393,0.00006737647,0.000006731097,0.00001749923,0.0002333915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06371874,"threshold_uncertainty_score":0.3888214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008003726199823683,"score_gpt":0.2777041235589989,"score_spread":0.2697003973591752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}