{"id":"W1968875985","doi":"10.1016/j.jmb.2015.04.008","title":"Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D)","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Toronto","funders":"U.S. Public Health Service; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; North Carolina Department of Health and Human Services; Foundation for the National Institutes of Health","keywords":"Biology; Lincosamides; Lincomycin; Enzyme; Antibiotics; Genetics; Antibiotic resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001110092,0.0001781862,0.0001474853,0.0001174591,0.0001019738,0.0002828713,0.0001694392,0.0002131233,0.0005979469],"category_scores_gemma":[0.0002754821,0.0001367331,0.0001883673,0.0001323237,0.000220332,0.0001872901,0.0001572349,0.0003718914,0.0003030523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003185989,"about_ca_system_score_gemma":0.0001947316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007437755,"about_ca_topic_score_gemma":0.0008306159,"domain_scores_codex":[0.9999343,0.00001266187,0.000007224457,0.0000175257,0.0000147041,0.00001352955],"domain_scores_gemma":[0.9998307,0.00003191423,0.00006066968,0.00002051557,0.00001843619,0.00003763888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000583291,0.000005080158,0.0002343824,0.000005300569,0.000002086786,0.0000192693,0.0000073664,0.00006164942,0.9990023,0.00009989201,0.000005561999,0.0004986957],"study_design_scores_gemma":[0.000007515252,0.00009130358,0.006536783,0.000002084674,0.00001032452,0.0002640738,0.00002877437,0.001346745,0.9901389,0.0001046342,0.001462739,0.000006147579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966038,0.0002695869,0.00252448,0.00005160105,0.000005432438,0.000005507898,0.0001366794,0.00001982583,0.0003830091],"genre_scores_gemma":[0.9969354,0.0001307543,0.001896574,0.00002287275,0.000002959043,0.000007210639,0.0004019485,0.00001094365,0.0005913243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007437755,"threshold_uncertainty_score":0.002311647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221684118106496,"score_gpt":0.2539733874038489,"score_spread":0.241756546222784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}