{"id":"W1968875985","doi":"10.1016/j.jmb.2015.04.008","title":"Structural and Functional Plasticity of Antibiotic Resistance Nucleotidylyltransferases Revealed by Molecular Characterization of Lincosamide Nucleotidylyltransferases Lnu(A) and Lnu(D)","year":2015,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University; University of Toronto","funders":"U.S. Public Health Service; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; North Carolina Department of Health and Human Services; Foundation for the National Institutes of Health","keywords":"Biology; Lincosamides; Lincomycin; Enzyme; Antibiotics; Genetics; Antibiotic resistance; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146855,0.0002387871,0.0004925832,0.0001278907,0.00003876869,0.00001498907,0.0001873331,0.0002680488,0.000009335275],"category_scores_gemma":[0.0003995676,0.0002085562,0.0001442389,0.0001459413,0.0005511614,0.00001451856,0.0000890643,0.000211709,2.678486e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001478519,"about_ca_system_score_gemma":0.0001533193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001213128,"about_ca_topic_score_gemma":0.000004549128,"domain_scores_codex":[0.9982241,0.0002475058,0.0006468919,0.0003332057,0.0002833154,0.0002649474],"domain_scores_gemma":[0.9986927,0.00004220532,0.0003126094,0.0001815642,0.0005252877,0.0002456408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009903272,0.00008637433,0.00381507,0.0001273912,0.000182195,0.00002100762,0.00002373828,0.0000103605,0.9936447,0.0005314925,0.0001072067,0.0004601856],"study_design_scores_gemma":[0.001660711,0.001161234,0.005010231,0.00008565385,0.00008463908,0.0001286621,0.00002904527,0.00002148142,0.9906875,0.0004157744,0.0005151808,0.0001998445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812123,0.003213838,0.01481578,0.0002865939,0.00008916338,0.0001719481,0.0001527907,0.000003934263,0.00005365852],"genre_scores_gemma":[0.9978194,0.0006270323,0.001150706,0.0001519768,0.00006262054,0.000001480744,0.0001382949,0.00002729264,0.00002123501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01660706,"threshold_uncertainty_score":0.8504674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221684118106496,"score_gpt":0.2539733874038489,"score_spread":0.241756546222784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}