{"id":"W1968895857","doi":"10.1371/journal.pone.0042325","title":"Rates of Decline in Alzheimer Disease Decrease with Age","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Canadian Institutes of Health Research; University of California, Los Angeles; National Institutes of Health; Eisai; National Institute of Neurological Disorders and Stroke; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amorfix Life Sciences; Dana Foundation; Synarc; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Atrophy; Cognitive decline; Medicine; Ageing; Disease; Clinical trial; Alzheimer's disease; Internal medicine; Sample size determination; Dementia","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007615197,0.0004164929,0.0006678355,0.0007363636,0.00022201,0.0008992968,0.0003697882,0.0007118366,0.001094557],"category_scores_gemma":[0.02072236,0.0002071,0.0007642446,0.0008018536,0.0003449639,0.0009549882,0.0006977724,0.0006835616,0.0004910195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002170745,"about_ca_system_score_gemma":0.0003576715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416028,"about_ca_topic_score_gemma":0.001019304,"domain_scores_codex":[0.997329,0.001161528,0.0002354706,0.0006862926,0.0004553065,0.0001322676],"domain_scores_gemma":[0.9910201,0.003508977,0.002941914,0.001310803,0.0009556722,0.0002625702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001283788,0.0001055048,0.9161948,0.000196737,0.0008891125,0.0000832007,0.0004755238,0.001486992,0.003904961,0.0004505949,0.0007840915,0.07414476],"study_design_scores_gemma":[0.00002260503,0.0007364125,0.9942657,0.00002494457,0.0001338433,0.0002475649,0.0001001829,0.0009744241,0.0008965842,0.0005380441,0.002046878,0.00001289614],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9687859,0.01256926,0.01120692,0.0004382352,0.00006545843,0.0002169546,0.002879612,0.0001695036,0.003668023],"genre_scores_gemma":[0.9908502,0.002570276,0.003442926,0.0002702389,0.00006698816,0.0001533365,0.001369159,0.00002213742,0.001254736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007615197,"threshold_uncertainty_score":0.04027349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09820741394125222,"score_gpt":0.3322432647903825,"score_spread":0.2340358508491303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}