{"id":"W1968949098","doi":"10.1016/s0140-6736(10)60284-x","title":"Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial","year":2010,"lang":"en","type":"article","venue":"The Lancet","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":906,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"University of California, San Diego","keywords":"Medicine; Placebo; Familial hypercholesterolemia; Internal medicine; Apolipoprotein B; Gastroenterology; Clinical endpoint; Cholesterol; Clinical trial; Intention-to-treat analysis; Endocrinology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248194,0.002009793,0.004553035,0.0005522312,0.0004424749,0.001074494,0.0009302877,0.002669988,0.006044842],"category_scores_gemma":[0.001421823,0.0009897065,0.002280031,0.000505625,0.0009566817,0.001083737,0.0003751592,0.003220013,0.0009592569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006381159,"about_ca_system_score_gemma":0.0007609287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001701343,"about_ca_topic_score_gemma":0.003286974,"domain_scores_codex":[0.9995877,0.000163058,0.00003579583,0.00007889934,0.00003897931,0.00009567721],"domain_scores_gemma":[0.9995639,0.0001376066,0.00008322741,0.00003197032,0.00003024542,0.0001531105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9864553,0.000988981,0.0002940451,0.0009082456,0.001325931,0.00005201422,0.00002954461,0.0001024117,0.00225251,0.00008366213,0.0007468835,0.006760479],"study_design_scores_gemma":[0.9844327,0.01241601,0.001392385,0.00003538921,0.0008667312,0.00003016542,0.00001661772,0.0001677271,0.000200916,0.00005290461,0.0003745282,0.00001386959],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605466,0.0248734,0.001473156,0.001721848,0.002006266,0.002882164,0.002024517,0.0004625414,0.004009587],"genre_scores_gemma":[0.9731065,0.01157415,0.002048713,0.002624606,0.001359493,0.00253562,0.001630692,0.00004869484,0.005071579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006044842,"threshold_uncertainty_score":0.02022201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398229010341136,"score_gpt":0.2774385225148751,"score_spread":0.2534562324114638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}