{"id":"W1968952077","doi":"10.1186/1471-2407-11-71","title":"Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice","year":2011,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Windsor Regional Hospital; University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; University of Windsor","keywords":"DNA methylation; Biology; Methylation; Cancer research; Downregulation and upregulation; Epigenetics; Bisulfite sequencing; Hepatocellular carcinoma; CpG site; Polo-like kinase; Molecular biology; Cancer; Genetics; Cell cycle; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003781756,0.001024763,0.0004474449,0.001939807,0.0005082587,0.0005167666,0.0006735383,0.001242363,0.006469301],"category_scores_gemma":[0.0002806695,0.0006787666,0.0006136306,0.0004273706,0.0007530908,0.0004445833,0.0005383406,0.001378225,0.001293608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006417026,"about_ca_system_score_gemma":0.0003733277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036588,"about_ca_topic_score_gemma":0.001519682,"domain_scores_codex":[0.999522,0.00004953667,0.00006989449,0.000176678,0.0001033126,0.00007853481],"domain_scores_gemma":[0.9991296,0.0001103937,0.000413292,0.00007897842,0.00005182575,0.0002159505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003864636,0.00007142923,0.0004164652,0.00004497464,0.00001551847,0.0001413682,0.00003633907,0.00008534972,0.9977634,0.0001431961,0.00005507619,0.0008405078],"study_design_scores_gemma":[0.0001235497,0.0006224759,0.007592998,0.00002155412,0.00006127365,0.0008323425,0.00007774703,0.001145515,0.9872233,0.0001465369,0.002135355,0.00001733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838575,0.0007014283,0.008559822,0.0002667417,0.0001043023,0.0001200337,0.004232866,0.0006750532,0.001482291],"genre_scores_gemma":[0.9659797,0.0009699207,0.01056541,0.000166099,0.00004464534,0.0005090308,0.0034854,0.0004625488,0.01781733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006469301,"threshold_uncertainty_score":0.02164197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02270650562695273,"score_gpt":0.2630066293806683,"score_spread":0.2403001237537155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}