{"id":"W1968959087","doi":"10.1016/j.cyto.2012.03.015","title":"MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression","year":2012,"lang":"en","type":"article","venue":"Cytokine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Université de Montréal","funders":"Canadian Institutes of Health Research; Roche Organ Transplant Research Foundation","keywords":"MHC class II; Cell biology; CD40; MHC class I; Chemistry; Ubiquitin ligase; Biology; Immune system; B cell; Molecular biology; T cell; Major histocompatibility complex; Cytotoxic T cell; Immunology; Ubiquitin; Antibody; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003622916,0.0002239701,0.0002972885,0.0002251851,0.0002380277,0.00001080439,0.0001882026,0.0003100249,0.004735357],"category_scores_gemma":[0.00009151117,0.0001900427,0.0000822285,0.0002343745,0.0001510293,0.0003368331,0.0001334934,0.0002680081,0.0006452581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007998414,"about_ca_system_score_gemma":0.00004036552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001860061,"about_ca_topic_score_gemma":0.000006052441,"domain_scores_codex":[0.9983955,0.0004639507,0.0003448332,0.0002180209,0.00004646147,0.00053124],"domain_scores_gemma":[0.9992144,0.000218968,0.0001309632,0.0003648501,0.0000440826,0.00002669841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002097746,0.00047557,0.001150678,0.00001060871,0.0000430054,0.000001424601,0.0004703836,0.000006883144,0.9865692,0.00009761305,0.005020143,0.004056754],"study_design_scores_gemma":[0.001506608,0.0001434589,0.04671739,0.00006447775,0.000009470155,0.00001973448,0.00008285192,0.000001721427,0.7441435,0.00002686112,0.2071071,0.0001768137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939044,0.004008995,0.00003818768,0.0001645529,0.0005101784,0.0002508987,0.00004325795,0.00009395149,0.0009856031],"genre_scores_gemma":[0.9872157,0.0001751602,0.00005025925,0.0001223002,0.00006446683,0.00003548849,0.0002687065,0.00002759281,0.01204034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2424256,"threshold_uncertainty_score":0.9961745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275251890665889,"score_gpt":0.2394350232519342,"score_spread":0.2266825043452753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}