{"id":"W1968959087","doi":"10.1016/j.cyto.2012.03.015","title":"MARCH1 down-regulation in IL-10-activated B cells increases MHC class II expression","year":2012,"lang":"en","type":"article","venue":"Cytokine","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Université de Montréal","funders":"Canadian Institutes of Health Research; Roche Organ Transplant Research Foundation","keywords":"MHC class II; Cell biology; CD40; MHC class I; Chemistry; Ubiquitin ligase; Biology; Immune system; B cell; Molecular biology; T cell; Major histocompatibility complex; Cytotoxic T cell; Immunology; Ubiquitin; Antibody; Gene; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001916406,0.000537206,0.0004623717,0.000317127,0.0003310242,0.000797814,0.0003663859,0.0004598377,0.004877532],"category_scores_gemma":[0.0002256279,0.0002760263,0.000454383,0.0002366915,0.0004258144,0.0003051496,0.0002814474,0.002230717,0.00164761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004644014,"about_ca_system_score_gemma":0.0003511971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005243114,"about_ca_topic_score_gemma":0.0009321189,"domain_scores_codex":[0.9996808,0.0000396139,0.00002931561,0.00004804302,0.000061469,0.0001407904],"domain_scores_gemma":[0.9998061,0.00003333819,0.00004246602,0.00002360954,0.00001648133,0.00007804353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006123233,0.00005446357,0.0001121857,0.00005099485,0.000006695745,0.00006204721,0.00001256926,0.00003646907,0.9980312,0.00005680966,0.0001350098,0.0008292623],"study_design_scores_gemma":[0.00009880101,0.0004372742,0.004984894,0.0000101314,0.00002931321,0.0003001876,0.00006819282,0.0004898901,0.9895918,0.00007323093,0.003909192,0.000007164258],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924467,0.002280106,0.001532181,0.0005737806,0.0003005137,0.00003440897,0.0008162634,0.0001750225,0.001840998],"genre_scores_gemma":[0.9901933,0.0008273535,0.001837075,0.0001975147,0.00009418028,0.00008636971,0.001661503,0.00005852824,0.005044098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004877532,"threshold_uncertainty_score":0.01631701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275251890665889,"score_gpt":0.2394350232519342,"score_spread":0.2266825043452753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}