{"id":"W1968967577","doi":"10.1038/cdd.2013.160","title":"Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiation","year":2013,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Associazione Italiana per la Ricerca sul Cancro; Ministero della Salute; McGill University","keywords":"HES1; Neurogenesis; PIN1; Cell biology; Psychological repression; Neural stem cell; Biology; Notch signaling pathway; Signal transduction; Stem cell; Isomerase; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006816806,0.0002191075,0.0001777072,0.00006170524,0.0001172195,0.00009479302,0.00006113113,0.0001329843,0.00004081805],"category_scores_gemma":[0.0001372977,0.0002078755,0.00004275229,0.00008854915,0.00005121226,0.00002482714,0.00009142351,0.00008598007,0.000005645437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001033911,"about_ca_system_score_gemma":0.00003069849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002288007,"about_ca_topic_score_gemma":0.000002610041,"domain_scores_codex":[0.9986744,0.0001353798,0.0003110154,0.000458258,0.0001810816,0.0002398451],"domain_scores_gemma":[0.9992658,0.00001801482,0.0001358325,0.0001908391,0.0001404663,0.0002490288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001202486,0.0002361783,0.01365488,0.0001145547,0.00001384584,0.000001039401,0.00004591112,0.000005698301,0.9844182,0.000008570017,0.0001873164,0.001193614],"study_design_scores_gemma":[0.0009342664,0.0003346907,0.1079528,0.00004080926,0.00004950595,0.000001570368,0.000008418117,0.002008151,0.8883907,0.00004614551,0.00003650563,0.0001964825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958485,0.0002998995,0.002651259,0.00008849693,0.00005968477,0.0009160499,0.00009788189,0.00002289476,0.00001530057],"genre_scores_gemma":[0.9982108,0.0000400451,0.0001867571,0.0001432635,0.00005693979,0.000159943,0.001096769,0.00002995769,0.00007553426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09602746,"threshold_uncertainty_score":0.8476917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007545292985979336,"score_gpt":0.203911151119072,"score_spread":0.1963658581330927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}