{"id":"W1968968763","doi":"10.1042/bj20081364","title":"The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sites","year":2009,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"ATP-binding cassette transporter; Cyclic nucleotide-binding domain; Binding site; Chemistry; Nucleotide; Biochemistry; Plasma protein binding; Transmembrane domain; Transporter; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001221633,0.0001781367,0.0002405266,0.00003724846,0.0002126261,0.00004990373,0.00009458391,0.00008789048,0.00005536375],"category_scores_gemma":[0.000008995802,0.00008276201,0.000108406,0.0000613345,0.0001160536,0.00004052108,0.000006540605,0.0004189363,0.000004310323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005244093,"about_ca_system_score_gemma":0.00002572556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":4.294513e-7,"about_ca_topic_score_gemma":0.000004492521,"domain_scores_codex":[0.9989181,0.00001524942,0.0002600767,0.000176695,0.0003332455,0.0002965892],"domain_scores_gemma":[0.9993534,0.00003735336,0.00008040247,0.0001445738,0.0000600694,0.000324209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002753803,0.0002420669,0.005479277,0.00004579753,0.0001083958,0.0002771933,0.001119143,1.389437e-7,0.9775042,0.0001224829,0.001507905,0.01083963],"study_design_scores_gemma":[0.006001836,0.001402915,0.1641289,0.001215524,0.0004861123,0.002956119,0.0005769593,0.00003942688,0.8109834,0.0009934029,0.01070716,0.0005081613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99199,0.001429535,0.0001665021,0.00584487,0.00009016278,0.0001178224,0.000002392228,0.00002341472,0.000335327],"genre_scores_gemma":[0.997328,0.0006566989,0.0002343385,0.0007642577,0.0003704616,0.000002315831,0.00001078555,0.0000137107,0.0006194118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1665207,"threshold_uncertainty_score":0.3374937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006815606082100308,"score_gpt":0.2243309588963385,"score_spread":0.2175153528142382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}