{"id":"W1968995247","doi":"10.1128/mcb.00325-07","title":"Glucose-Dependent Insulinotropic Polypeptide-Mediated Up-Regulation of β-Cell Antiapoptotic <i>Bcl-2</i> Gene Expression Is Coordinated by Cyclic AMP (cAMP) Response Element Binding Protein (CREB) and cAMP-Responsive CREB Coactivator 2","year":2007,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"CREB; Coactivator; Protein kinase A; Biology; Cyclic AMP Response Element-Binding Protein; CREB1; AMPK; Phosphorylation; Cell biology; AMP-activated protein kinase; Signal transduction; Endocrinology; Molecular biology; Transcription factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007747927,0.0004338641,0.0001957327,0.0001688916,0.0001217307,0.0002536314,0.0001178541,0.0001127144,0.00189403],"category_scores_gemma":[0.00005994472,0.0001155999,0.0002733485,0.0001218563,0.0001769192,0.0001363451,0.0001659693,0.0005548317,0.0003375562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133494,"about_ca_system_score_gemma":0.0001012751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002761929,"about_ca_topic_score_gemma":0.0003983779,"domain_scores_codex":[0.999915,0.00001156816,0.000005848111,0.00001802149,0.00002148403,0.0000280481],"domain_scores_gemma":[0.9999337,0.000007369712,0.00001920751,0.000008516326,0.000009619885,0.000021553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001499417,0.00003044642,0.000129373,0.00004553051,0.000005953622,0.00005185822,0.000008291042,0.00001325594,0.9983208,0.00004902127,0.00008886159,0.001106716],"study_design_scores_gemma":[0.00006478113,0.0004178715,0.01566054,0.00001241281,0.0000217195,0.0003616349,0.00004085044,0.0004672269,0.9780673,0.00006501502,0.004814592,0.000006069213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888068,0.003216682,0.002649923,0.0002541572,0.0001312437,0.00003124213,0.0004950063,0.0002125721,0.004202404],"genre_scores_gemma":[0.9925104,0.002234841,0.001470427,0.0001479567,0.00003964776,0.00004756851,0.0008508197,0.00003622851,0.002662174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00189403,"threshold_uncertainty_score":0.006336153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006983041514037881,"score_gpt":0.2329176169994184,"score_spread":0.2259345754853805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}