{"id":"W1969013845","doi":"10.1038/tp.2013.13","title":"Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)","year":2013,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; University of California, Irvine; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Genentech; National Institutes of Health; University of California, San Francisco; Alzheimer Society; Northern California Institute for Research and Education; Rush University; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Johns Hopkins University; University of Washington; National Center for Research Resources; F. Hoffmann-La Roche; Medpace; Emory University; Vanderbilt University; Massachusetts General Hospital; GlaxoSmithKline; York University; University of Miami; Northwestern University; Pfizer; University of Pennsylvania; Elan; Novartis; University of California, San Diego; U.S. Department of Veterans Affairs; Synarc; Wellcome Trust; University of Southern California; Dana Foundation; Alzheimer's Association; Eli Lilly and Company; Bristol-Myers Squibb; AstraZeneca; University of California, Davis; Eisai; Howard Hughes Medical Institute","keywords":"Single-nucleotide polymorphism; Biology; Amyloid precursor protein; Genetics; Linkage disequilibrium; Alzheimer's disease; Gene; Medicine; Disease; Internal medicine; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001006763,0.0001304324,0.0001920237,0.00009193656,0.00005460506,0.00000914218,0.0000487078,0.00004638306,0.00004794543],"category_scores_gemma":[0.00003029631,0.00008686786,0.00005272418,0.0001560092,0.0001443302,0.0001002415,0.00001011403,0.0001611415,0.000004233157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008411374,"about_ca_system_score_gemma":0.0002864356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000841739,"about_ca_topic_score_gemma":0.00001738982,"domain_scores_codex":[0.9988703,0.0001110433,0.0002438428,0.0002188126,0.0004020103,0.0001540368],"domain_scores_gemma":[0.9994254,0.00008274232,0.000109448,0.0001431349,0.00005425449,0.0001849845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009912321,0.001207584,0.9792143,0.001107301,0.0008964159,0.000002944364,0.0003528164,0.000007424297,0.0001559715,0.000460125,0.00003815829,0.01556575],"study_design_scores_gemma":[0.002939961,0.0002073993,0.9871718,0.0008707389,0.0004074935,0.000001579939,0.00002891325,0.0003500781,0.0002537991,0.007691453,0.00000301492,0.00007380205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823396,0.01423591,0.00002392815,0.001192868,0.00004867852,0.001953852,0.00004385199,0.000008108187,0.0001532385],"genre_scores_gemma":[0.9989824,0.00006911805,0.0007306573,0.00003473422,0.00002188385,0.0001187293,0.00001479791,0.0000148792,0.00001284534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01664279,"threshold_uncertainty_score":0.3542369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01086794519737552,"score_gpt":0.2720865532263859,"score_spread":0.2612186080290104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}