{"id":"W1969049470","doi":"10.1007/s11434-014-0417-0","title":"New insights into mTOR structure and regulation","year":2014,"lang":"en","type":"article","venue":"Chinese Science Bulletin","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"National Natural Science Foundation of China","keywords":"PI3K/AKT/mTOR pathway; RPTOR; Cell biology; Chemistry; Protein kinase B; mTORC2; Protein kinase domain; Domain (mathematical analysis); Mechanistic target of rapamycin; Signal transduction; Biology; Biochemistry; mTORC1; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002201292,0.0004242985,0.0004367335,0.0007940147,0.0004719682,0.0007657558,0.0003387292,0.0003697126,0.002097905],"category_scores_gemma":[0.0001300565,0.0002316928,0.0003171699,0.0006473461,0.0007134757,0.001485497,0.0004202033,0.0009251539,0.0003246608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009578604,"about_ca_system_score_gemma":0.0008239716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001355337,"about_ca_topic_score_gemma":0.001688631,"domain_scores_codex":[0.9999503,0.000004711002,0.000004826244,0.00001398669,0.00001649599,0.00000984735],"domain_scores_gemma":[0.999963,0.000009058977,0.000006867969,0.000004311088,0.000009064181,0.000007609191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004791816,0.000133087,0.002329777,0.002167008,0.0001104594,0.00130099,0.0005521763,0.003379737,0.3308701,0.1948285,0.01352181,0.4503271],"study_design_scores_gemma":[0.0001261415,0.0003607049,0.02241663,0.0002192446,0.0003752308,0.00208477,0.0006438735,0.01243923,0.1426501,0.1386995,0.6798589,0.0001257193],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2002936,0.6550116,0.0406477,0.02242688,0.003277262,0.00006490594,0.0008298085,0.0006502387,0.0767981],"genre_scores_gemma":[0.5811496,0.3765485,0.01058557,0.002081652,0.003474534,0.00008159438,0.0006078995,0.0000615956,0.02540905],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002097905,"threshold_uncertainty_score":0.007018209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003138451791007226,"score_gpt":0.2318604950080724,"score_spread":0.2287220432170652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}