{"id":"W1969063831","doi":"10.1158/1538-7445.am10-1588","title":"Abstract 1588: NR2F6, a novel regulator of stem cell maintenance, is necessary and sufficient for initiation of acute leukemia","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; Ontario Institute for Cancer Research; Sunnybrook Hospital","funders":"","keywords":"Stem cell; Haematopoiesis; Chronic myelomonocytic leukemia; Progenitor cell; Biology; Clonogenic assay; Cancer research; Myeloid leukemia; Leukemia; CD34; Myeloid; Bone marrow; Population; Immunology; Medicine; Cell; Cell biology; Myelodysplastic syndromes; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278535,0.0003515074,0.0002887286,0.0001984909,0.0002119894,0.0002519478,0.0003397676,0.0003608764,0.005505978],"category_scores_gemma":[0.0001172432,0.0001423097,0.0001734694,0.0001095674,0.0002783237,0.0001515873,0.0001811526,0.0004853866,0.00207912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003236419,"about_ca_system_score_gemma":0.0001350051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002713299,"about_ca_topic_score_gemma":0.0004190017,"domain_scores_codex":[0.9998466,0.00001708766,0.00001774152,0.0000419777,0.00005102587,0.0000255676],"domain_scores_gemma":[0.9998296,0.00002434245,0.00005761086,0.00001605732,0.00001261698,0.00005974834],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001922583,0.00002379435,0.0002090847,0.00003008011,0.000002153725,0.0001128071,0.000004811734,0.00002841454,0.9982319,0.00005435932,0.0001327484,0.0009775128],"study_design_scores_gemma":[0.0001277599,0.0006393763,0.01575726,0.00001727339,0.0000240199,0.002740553,0.00003651138,0.001710027,0.9649919,0.0001381996,0.01380728,0.000009781482],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862331,0.003253531,0.003801975,0.0003283978,0.000142836,0.0000538008,0.002694296,0.0002873795,0.003204729],"genre_scores_gemma":[0.982857,0.0005992602,0.003082064,0.0001362647,0.00008242833,0.00005208824,0.00524787,0.00009370618,0.007849287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005505978,"threshold_uncertainty_score":0.01841933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03897622038132897,"score_gpt":0.3484672154305348,"score_spread":0.3094909950492059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}