{"id":"W1969077273","doi":"10.1021/bi048328i","title":"Light-Driven Activation of β<sub>2</sub>-Adrenergic Receptor Signaling by a Chimeric Rhodopsin Containing the β<sub>2</sub>-Adrenergic Receptor Cytoplasmic Loops","year":2005,"lang":"en","type":"article","venue":"Biochemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":167,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; National Institute of General Medical Sciences; University of British Columbia; University of Texas Southwestern Medical Center","keywords":"Rhodopsin; Transducin; Transmembrane domain; G protein-coupled receptor; Receptor; Biophysics; Cytoplasm; Signal transduction; Transmembrane protein; Chemistry; Biology; Cell biology; Biochemistry; Retinal","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005253902,0.000598066,0.0005548574,0.0001064609,0.000231316,0.00007319975,0.0006111474,0.0006295252,0.0000918461],"category_scores_gemma":[0.0001669817,0.0005430505,0.0003243944,0.0004547443,0.0001279523,0.00002940521,0.000191295,0.0004278361,0.00002795819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001672378,"about_ca_system_score_gemma":0.0002581277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002142406,"about_ca_topic_score_gemma":0.000009645327,"domain_scores_codex":[0.9967564,0.0001733171,0.0008981589,0.000980056,0.0004619985,0.0007300671],"domain_scores_gemma":[0.998205,0.00007967369,0.000607948,0.0007020545,0.000197131,0.0002081621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003947455,0.0001638748,0.0001717496,0.00006436057,0.0001166106,0.000001558758,0.0001351028,0.001441381,0.989033,0.00001727722,0.001666644,0.006793687],"study_design_scores_gemma":[0.001130694,0.0003075431,0.00002352082,0.0002064119,0.00004065184,0.00001622677,0.0003925269,0.0005388432,0.9939893,0.00001752721,0.002694137,0.0006426172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964492,0.001674563,0.0006774586,0.0002583355,0.0002418865,0.0003321313,0.00005777958,0.00005074298,0.0002578678],"genre_scores_gemma":[0.9964167,0.000697208,0.0008519127,0.0002452074,0.0008772946,0.0001044998,0.0006151608,0.0001073785,0.00008457946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006151069,"threshold_uncertainty_score":0.9997021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006974240511496936,"score_gpt":0.2094556985373188,"score_spread":0.2024814580258219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}