{"id":"W1969090843","doi":"10.1099/mic.0.028456-0","title":"Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system","year":2009,"lang":"en","type":"article","venue":"Microbiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institutes of Health","keywords":"Operon; Two-component regulatory system; Streptococcus mutans; lac operon; Biology; Gene; Gene expression; Response regulator; Regulation of gene expression; Mutant; Microbiology; Cell biology; Genetics; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526963,0.0003411428,0.0003066878,0.0002283403,0.0001084316,0.0003122789,0.0001307034,0.0001587963,0.0005274385],"category_scores_gemma":[0.0001891917,0.0001209437,0.000264639,0.0001115505,0.000189963,0.0001532233,0.0003057349,0.0002950862,0.0002911038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003389563,"about_ca_system_score_gemma":0.0002569141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006254632,"about_ca_topic_score_gemma":0.0004947904,"domain_scores_codex":[0.9997787,0.00003620143,0.00001772288,0.00004760894,0.00007708821,0.00004269473],"domain_scores_gemma":[0.9998249,0.00003720265,0.0000589091,0.00001843295,0.00003035998,0.0000301928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002808284,0.000004820917,0.0001333936,0.000008646465,6.480479e-7,0.00001797072,0.000007126151,0.00001703986,0.9994096,0.00002306848,0.00000575332,0.0003439156],"study_design_scores_gemma":[0.000006598283,0.0001232257,0.01326585,0.00000643805,0.000008417574,0.0003223496,0.0000664067,0.001993265,0.9833202,0.00006046579,0.0008168948,0.000009948498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951563,0.0005279559,0.003348309,0.00006351481,0.000009418223,0.00001739626,0.0002282785,0.00009408713,0.0005547484],"genre_scores_gemma":[0.996412,0.0001435389,0.002000655,0.00002268902,0.000004422257,0.00001529216,0.00043655,0.0000207793,0.0009442163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006254632,"threshold_uncertainty_score":0.002459288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006364837632779632,"score_gpt":0.2436052358338167,"score_spread":0.2372403982010371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}