{"id":"W1969107609","doi":"10.1177/1933719110377237","title":"Lactobacillus rhamnosus GR-1-Induced IL-10 Production in Human Placental Trophoblast Cells Involves Activation of JAK/STAT and MAPK Pathways","year":2010,"lang":"en","type":"article","venue":"Reproductive Sciences","topic":"Preterm Birth and Chorioamnionitis","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Western University; Lawson Health Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Trophoblast; Lactobacillus rhamnosus; Janus kinase; p38 mitogen-activated protein kinases; JAK-STAT signaling pathway; Biology; Cytokine; Signal transduction; Kinase; MAPK/ERK pathway; STAT3; Cell biology; Molecular biology; Chemistry; Placenta; Immunology; Biochemistry; Lactobacillus; Fetus; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063942,0.0003539648,0.0002315627,0.0003036032,0.0001668055,0.0002989207,0.0001150934,0.0001955818,0.002132599],"category_scores_gemma":[0.0001884236,0.0001685952,0.0003622617,0.0001683106,0.0002034855,0.0001474811,0.0002565648,0.0006057113,0.0004924379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958784,"about_ca_system_score_gemma":0.0004129878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117292,"about_ca_topic_score_gemma":0.001440064,"domain_scores_codex":[0.9998191,0.00006043107,0.00001806002,0.00001560185,0.00002730263,0.00005952562],"domain_scores_gemma":[0.9999254,0.00002288523,0.00001125066,0.0000110587,0.00001038059,0.00001912535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001045938,0.0001016051,0.0006292557,0.0001363397,0.00001011202,0.0003144453,0.00005896792,0.00007065407,0.9946972,0.0001079453,0.0001522807,0.002675273],"study_design_scores_gemma":[0.0001889732,0.0009897341,0.02675344,0.00003425535,0.00004555897,0.0008108898,0.0002746298,0.001080223,0.9659205,0.0001759824,0.00371512,0.00001074078],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915037,0.00251224,0.001349097,0.0004209311,0.0000998295,0.00008044178,0.0008441932,0.00005442128,0.003135142],"genre_scores_gemma":[0.9933906,0.001214524,0.001486948,0.0001265593,0.00002793637,0.0001020448,0.001015959,0.000009261319,0.002626141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002132599,"threshold_uncertainty_score":0.007134259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02827026249993731,"score_gpt":0.2696486503099902,"score_spread":0.2413783878100529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}