{"id":"W1969111628","doi":"10.1016/s0167-4838(02)00204-2","title":"Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences","year":2002,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"University of Pennsylvania","keywords":"Kallikrein; Biochemistry; Chemistry; Prostate-specific antigen; Molecular biology; Protease; Proteolysis; Serine protease; Chymotrypsin; Trypsin; Enzyme; Biology; Prostate; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009510868,0.0004302686,0.000694078,0.0001293023,0.0001590464,0.00004685525,0.0001226278,0.000304778,0.0000640324],"category_scores_gemma":[0.00003874034,0.0003846183,0.0001401886,0.0001750795,0.0004140505,0.0000961607,0.00006386706,0.0001838825,0.000001828927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001996978,"about_ca_system_score_gemma":0.00008861184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002473954,"about_ca_topic_score_gemma":0.00001500084,"domain_scores_codex":[0.9980233,0.0001545816,0.000480278,0.0007323945,0.000197817,0.0004115793],"domain_scores_gemma":[0.9988983,0.0001213218,0.0002890976,0.0003416089,0.0001424055,0.0002072112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004038558,0.00005656107,0.00002074569,0.00006157842,0.0003122657,0.00003929361,0.001642795,0.000004753988,0.9954588,0.0006635837,0.0001531834,0.00118257],"study_design_scores_gemma":[0.001976461,0.001127691,0.003013589,0.0000989931,0.0001932044,0.0000542751,0.0001387656,0.0001974647,0.9858956,0.00682998,0.0001033596,0.0003705837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911231,0.004130707,0.001827157,0.0009848319,0.00005611049,0.001661602,0.000147722,0.00005636048,0.00001239924],"genre_scores_gemma":[0.9867666,0.0004626128,0.01179013,0.0003734479,0.0001506141,0.0000346406,0.0002988672,0.00005582319,0.00006728814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009962971,"threshold_uncertainty_score":0.9998606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02727977792147933,"score_gpt":0.2567774964469886,"score_spread":0.2294977185255093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}