{"id":"W1969123018","doi":"10.1016/j.yrtph.2013.08.015","title":"Genotoxicity and subchronic oral toxicity of l-ornithine monohydrochloride","year":2013,"lang":"en","type":"article","venue":"Regulatory Toxicology and Pharmacology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Intertek (Canada)","funders":"","keywords":"Genotoxicity; Ornithine; Chemistry; No-observed-adverse-effect level; Toxicity; Oral administration; Internal medicine; Endocrinology; Urea; Urine; Urea cycle; Excretion; Pharmacology; Biology; Biochemistry; Medicine; Arginine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183555,0.0001707434,0.0002757785,0.00006205413,0.0001090299,0.000006075416,0.0001354432,0.0002640971,0.0002467122],"category_scores_gemma":[0.00001872684,0.0001640687,0.00004407222,0.0000763375,0.0005575664,0.00001009235,0.0001803882,0.0001274739,0.000008650824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000827047,"about_ca_system_score_gemma":0.00006238058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001720101,"about_ca_topic_score_gemma":0.00001735575,"domain_scores_codex":[0.9989407,0.0001187133,0.0002541479,0.0003531098,0.0000528481,0.0002804798],"domain_scores_gemma":[0.999444,0.00003605009,0.0001169625,0.0001949431,0.00005766421,0.0001503752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000492648,0.00009791513,0.00371901,0.00002751558,0.00007343702,8.699958e-7,0.00002694289,0.00001111188,0.9901422,0.0007854878,0.002239966,0.002826263],"study_design_scores_gemma":[0.0009482001,0.0002706698,0.0658436,0.000001845319,0.00006726136,0.000049318,0.00001541168,0.0002144712,0.918768,0.0008211708,0.01282289,0.0001771195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957824,0.002829911,0.0002379434,0.0003660913,0.00016386,0.0003640222,0.00002148593,0.00001477279,0.0002195665],"genre_scores_gemma":[0.9974321,0.0006090921,0.0003532966,0.0008887687,0.0001884681,0.0001081141,0.00002422174,0.00001464316,0.0003813533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07137418,"threshold_uncertainty_score":0.6690526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008615492709957569,"score_gpt":0.2613412477990213,"score_spread":0.2527257550890638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}