{"id":"W1969201132","doi":"10.1021/cn1000759","title":"Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor","year":2010,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Alkene; Internalization; Enkephalin; Amide; Chemistry; Dipeptide; Stereochemistry; Biological activity; Peptide bond; Opioid receptor; Receptor; Intermolecular force; Combinatorial chemistry; Opioid peptide; Peptide; Opioid; Biochemistry; Molecule; Organic chemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001703256,0.0003556095,0.0001915714,0.0001006251,0.00008033637,0.0001573633,0.0001977699,0.0002291763,0.0006243914],"category_scores_gemma":[0.0002363834,0.000122792,0.0001614406,0.0001362007,0.0001331269,0.0003126352,0.0001573935,0.0004116232,0.0002161035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001165079,"about_ca_system_score_gemma":0.0001844563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002129438,"about_ca_topic_score_gemma":0.0005045812,"domain_scores_codex":[0.9999294,0.0000153589,0.000009498154,0.00001469317,0.00001431231,0.000016654],"domain_scores_gemma":[0.9998722,0.00003120035,0.00004704549,0.00001491245,0.00001822938,0.00001632681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008486184,0.00002292619,0.0001056485,0.00003239881,0.000004205822,0.00003719298,0.000008439555,0.0002430117,0.9973514,0.00007108021,0.000007791413,0.002031007],"study_design_scores_gemma":[0.00002009075,0.0007067296,0.0007715408,0.000005978291,0.00001809552,0.0001547971,0.00001615902,0.0004786756,0.9962397,0.00003945037,0.001542005,0.000006892058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940164,0.0008901093,0.003525714,0.00004041543,0.00001243436,0.00006169421,0.0001023836,0.00001703338,0.001333817],"genre_scores_gemma":[0.9882115,0.001623045,0.008781642,0.00007226282,0.000007749516,0.00004160364,0.0001418395,0.00001397641,0.001106283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006243914,"threshold_uncertainty_score":0.002088785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.155144067333628,"score_gpt":0.3101595805782956,"score_spread":0.1550155132446676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}