{"id":"W1969202288","doi":"10.1007/s13311-014-0311-0","title":"Early-Stage Treatment with Withaferin A Reduces Levels of Misfolded Superoxide Dismutase 1 and Extends Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis","year":2014,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Fonds de Recherche du Québec - Santé; Muscular Dystrophy Association","keywords":"SOD1; Amyotrophic lateral sclerosis; Withaferin A; Superoxide dismutase; Transgene; Neuroprotection; Genetically modified mouse; Neuroinflammation; Heat shock protein; Oxidative stress; Medicine; Biology; Cell biology; Pharmacology; Immunology; Endocrinology; Internal medicine; Biochemistry; Pathology; Gene; Inflammation; Disease; Withania somnifera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565106,0.000292751,0.0006451052,0.0002302769,0.00003618143,0.00002041266,0.0001339258,0.000114639,0.00003014674],"category_scores_gemma":[0.00001768602,0.000206986,0.00007793128,0.0002443157,0.0003327564,0.0001039939,0.00004035982,0.0002074334,0.000001302703],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007129158,"about_ca_system_score_gemma":0.0001076518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004526267,"about_ca_topic_score_gemma":0.00007019893,"domain_scores_codex":[0.9981058,0.0001559473,0.0004576677,0.0004072339,0.0004559891,0.0004173414],"domain_scores_gemma":[0.9990149,0.0000781371,0.0001255363,0.0004772351,0.00009604287,0.0002081453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001514714,0.0005185771,0.0406052,0.0001172951,0.0001022866,0.00001051713,0.001451316,0.0005818382,0.9465806,0.00008069064,6.107838e-7,0.008436332],"study_design_scores_gemma":[0.01091969,0.009159277,0.5473953,0.0004186833,0.0001526998,0.00001750386,0.0000653921,0.051878,0.3794847,0.00008010884,0.00004681465,0.0003818019],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984618,0.00007233651,0.0001618794,0.0004844799,0.00001054281,0.0006176979,0.0001029647,0.00003067052,0.00005760183],"genre_scores_gemma":[0.9968537,0.0004137809,0.001356607,0.0001880924,0.00002466851,0.00005032087,0.000004127547,0.00007596194,0.001032712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5670959,"threshold_uncertainty_score":0.8440644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08241947683989194,"score_gpt":0.2955812567577607,"score_spread":0.2131617799178688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}