{"id":"W1969202288","doi":"10.1007/s13311-014-0311-0","title":"Early-Stage Treatment with Withaferin A Reduces Levels of Misfolded Superoxide Dismutase 1 and Extends Lifespan in a Mouse Model of Amyotrophic Lateral Sclerosis","year":2014,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"Canadian Institutes of Health Research; ALS Society of Canada; Fonds de Recherche du Québec - Santé; Muscular Dystrophy Association","keywords":"SOD1; Amyotrophic lateral sclerosis; Withaferin A; Superoxide dismutase; Transgene; Neuroprotection; Genetically modified mouse; Neuroinflammation; Heat shock protein; Oxidative stress; Medicine; Biology; Cell biology; Pharmacology; Immunology; Endocrinology; Internal medicine; Biochemistry; Pathology; Gene; Inflammation; Disease; Withania somnifera","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002449242,0.001009043,0.0008592415,0.001004303,0.0002505087,0.0003274067,0.0004674109,0.0009459115,0.001313247],"category_scores_gemma":[0.0001254164,0.0002957862,0.0005971714,0.0003209885,0.000407456,0.0004006625,0.0002892215,0.001511608,0.0004482731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003535658,"about_ca_system_score_gemma":0.0002920069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007788449,"about_ca_topic_score_gemma":0.001395198,"domain_scores_codex":[0.9997353,0.00003198394,0.00003856506,0.00007781357,0.0000564475,0.00005977365],"domain_scores_gemma":[0.9996998,0.00001265451,0.00009936866,0.00002388444,0.0000262338,0.0001380737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004874832,0.0002219663,0.0001436381,0.00005814547,0.00001671655,0.00005888571,0.0000189752,0.00005196978,0.9976196,0.0000337034,0.00008678509,0.001202166],"study_design_scores_gemma":[0.0002163017,0.006994608,0.01129234,0.00004115376,0.0001177571,0.0005529601,0.00006006964,0.001167283,0.9751047,0.0001647324,0.004258756,0.00002937908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992607,0.0030595,0.00181042,0.0002171902,0.0001042945,0.00007625278,0.000918633,0.0004045148,0.0008022097],"genre_scores_gemma":[0.9835891,0.003337091,0.004314838,0.0002129503,0.00005364439,0.0002626253,0.001710414,0.00007189504,0.006447385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313247,"threshold_uncertainty_score":0.00439322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08241947683989194,"score_gpt":0.2955812567577607,"score_spread":0.2131617799178688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}