{"id":"W1969210187","doi":"10.1038/nrg2142","title":"Translation matters: protein synthesis defects in inherited disease","year":2007,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Translation (biology); Biology; Protein biosynthesis; Genetics; Phenotype; Disease; Gene; Messenger RNA; Computational biology; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001227663,0.001868757,0.002643988,0.001928613,0.0004019088,0.001406251,0.001932603,0.003912887,0.0021283],"category_scores_gemma":[0.001170882,0.0005298387,0.0004569111,0.002561969,0.001697079,0.001613726,0.001097908,0.003628882,0.002362816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001013187,"about_ca_system_score_gemma":0.0008390237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007991604,"about_ca_topic_score_gemma":0.001978651,"domain_scores_codex":[0.9996699,0.00005266493,0.00004794716,0.00006001363,0.0001380269,0.00003148992],"domain_scores_gemma":[0.9993737,0.0003255415,0.00007082484,0.00002310909,0.0001371579,0.00006971391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001490563,0.00004984263,0.0002647684,0.00500604,0.0001041677,0.0007653257,0.00005210526,0.0005327172,0.004085271,0.00769285,0.1203014,0.8609966],"study_design_scores_gemma":[0.00005585424,0.0000408227,0.0006891538,0.001211366,0.0001369627,0.003655764,0.0000593507,0.0002016017,0.001290928,0.007285777,0.985347,0.00002534415],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009102978,0.9963925,0.0005174046,0.00116661,0.0011356,0.00000279129,0.00001694933,0.00002119244,0.0006559338],"genre_scores_gemma":[0.0008033041,0.9954608,0.0003744499,0.001027778,0.001479912,0.000006980517,0.0000326665,0.000004028625,0.0008100458],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003912887,"threshold_uncertainty_score":0.00735122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05811752050683185,"score_gpt":0.3649863247653681,"score_spread":0.3068688042585362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}