{"id":"W1969210187","doi":"10.1038/nrg2142","title":"Translation matters: protein synthesis defects in inherited disease","year":2007,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Translation (biology); Biology; Protein biosynthesis; Genetics; Phenotype; Disease; Gene; Messenger RNA; Computational biology; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000507725,0.000488411,0.00100946,0.000187114,0.00004311972,0.00003631887,0.0003921998,0.001069263,0.00002920321],"category_scores_gemma":[0.0001247632,0.000406738,0.0005723448,0.0004833382,0.0000481458,0.000003021232,0.00004703084,0.0005963791,0.00004398638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006735252,"about_ca_system_score_gemma":0.0002312744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000148937,"about_ca_topic_score_gemma":0.00002537003,"domain_scores_codex":[0.997628,0.0003633384,0.0008201145,0.0006710705,0.0001905501,0.000326918],"domain_scores_gemma":[0.9985295,0.00002682035,0.0003647555,0.0008710452,0.00005807175,0.0001498065],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008921465,0.00005014135,0.0000059146,0.009345901,0.00002928423,0.000004736862,0.000003597147,0.00000133204,0.0002417876,0.000008227626,0.0009234175,0.9893767],"study_design_scores_gemma":[0.00009074384,0.00002152056,0.00002358296,0.008184899,0.00032026,0.000004830551,0.000001108936,0.000002438168,0.0001149995,0.00000771161,0.990801,0.0004268466],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005491281,0.9967151,0.0002819326,0.0000499596,0.0001251719,0.002497225,0.00007770239,0.00001051965,0.0001875241],"genre_scores_gemma":[0.00005397282,0.9959744,0.00160593,0.0002856997,0.0003539445,0.0009567983,0.0005057709,0.00008735432,0.0001761279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9898776,"threshold_uncertainty_score":0.9998385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05811752050683185,"score_gpt":0.3649863247653681,"score_spread":0.3068688042585362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}