{"id":"W1969230335","doi":"10.1021/bi900852m","title":"Effects of Phospholamban Transmembrane Mutants on the Calcium Affinity, Maximal Activity, and Cooperativity of the Sarcoplasmic Reticulum Calcium Pump","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"","keywords":"SERCA; Phospholamban; Chemistry; Calcium ATPase; Calcium; Biophysics; Calcium pump; Endoplasmic reticulum; Transmembrane domain; Cooperativity; Calcium-binding protein; Biochemistry; Mutant; Amino acid; ATPase; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005124652,0.0007059634,0.0005086797,0.0001903939,0.0002226529,0.0005267848,0.00058919,0.0005559993,0.001061174],"category_scores_gemma":[0.001015925,0.0003145924,0.0004045445,0.0002180478,0.0005430536,0.0003390158,0.0003225709,0.0007960503,0.000236109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006485073,"about_ca_system_score_gemma":0.0003592133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013194,"about_ca_topic_score_gemma":0.0007241254,"domain_scores_codex":[0.9995674,0.0001264121,0.00008017032,0.00007503638,0.0000884181,0.00006254296],"domain_scores_gemma":[0.9991763,0.0003235568,0.0002232168,0.00007344593,0.00006059142,0.0001428573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001214933,0.0002783151,0.0005833757,0.0000712207,0.00005362374,0.00025262,0.00007495908,0.002063014,0.9937592,0.0005253832,0.00005925625,0.001064133],"study_design_scores_gemma":[0.0001391255,0.00078747,0.002274885,0.00001583782,0.00007121656,0.0002835414,0.0000702847,0.01177206,0.9836447,0.0001236022,0.0007819576,0.00003545253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988368,0.0001917518,0.0005808035,0.0000471183,0.0000150038,0.00001359139,0.00006636842,0.00002337981,0.0002252025],"genre_scores_gemma":[0.9986632,0.0001467048,0.0008390396,0.00002598057,0.000004879743,0.00001508423,0.00006685513,0.00003314395,0.0002051059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001061174,"threshold_uncertainty_score":0.00470531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098020494157344,"score_gpt":0.2343384051113203,"score_spread":0.2233582001697468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}