{"id":"W1969241521","doi":"10.1074/jbc.m108255200","title":"Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":381,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"Medical Research and Materiel Command; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Army; National Institutes of Health; U.S. Department of Defense","keywords":"LNCaP; MAPK/ERK pathway; Androgen receptor; Signal transduction; Transactivation; Phosphorylation; Cancer research; Cell biology; Protein kinase A; Chemistry; Biology; Prostate cancer; Endocrinology; Internal medicine; Transcription factor; Medicine; Biochemistry; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001611312,0.0001179357,0.000160607,0.0000100302,0.00004761984,0.000008387344,0.0001416107,0.0002729505,0.0001190054],"category_scores_gemma":[0.00003080692,0.00006940294,0.0001367628,0.00005358759,0.0001581947,0.000006050121,0.00003427669,0.0002296358,6.198163e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001615296,"about_ca_system_score_gemma":0.00001332834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.506583e-7,"about_ca_topic_score_gemma":2.922759e-8,"domain_scores_codex":[0.99927,0.00006713535,0.000291097,0.0001368464,0.0001113697,0.0001236149],"domain_scores_gemma":[0.9994806,0.00001800131,0.0002755257,0.00009320857,0.00006057612,0.0000720656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722829,0.00009904651,0.0005442171,0.00002025737,0.0000560954,0.000003100586,0.00004123871,0.000002731388,0.9941929,0.000001033304,0.001016166,0.003850942],"study_design_scores_gemma":[0.0005105833,0.0005015546,0.000140557,0.00003358383,0.0000157598,0.0003406024,0.00007214143,0.00001496903,0.9958194,0.00006716813,0.002396995,0.00008670238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978388,0.001372494,0.0003969978,0.0001308394,0.00005092061,0.00005767004,0.00001479232,0.000002568611,0.0001349362],"genre_scores_gemma":[0.9990742,0.0004508698,0.0001879785,0.00003725212,0.0001611167,0.000001591747,0.00001552028,0.000006371574,0.00006513176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00376424,"threshold_uncertainty_score":0.283017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00965443901703879,"score_gpt":0.2038364861645673,"score_spread":0.1941820471475285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}