{"id":"W1969265330","doi":"10.1073/pnas.042686099","title":"WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Arthritis Network; University of Toronto; Arthritis Society","keywords":"Cofilin; Actin; Wiskott–Aldrich syndrome protein; Cell biology; Biology; Cytoskeleton; Actin-binding protein; Actin cytoskeleton; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006018971,0.0002748331,0.0001098349,0.0001536558,0.0001744207,0.0002870568,0.0001281276,0.0001531579,0.0005996116],"category_scores_gemma":[0.0001263873,0.0001251565,0.0001137756,0.00007356755,0.0002482673,0.0001339733,0.0001828208,0.0003298485,0.000283251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729495,"about_ca_system_score_gemma":0.000178811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004401248,"about_ca_topic_score_gemma":0.0005851433,"domain_scores_codex":[0.9999083,0.00001342506,0.000005577109,0.00001540597,0.00003156127,0.00002560254],"domain_scores_gemma":[0.9998802,0.00001202065,0.00003802938,0.00001082405,0.00001051338,0.00004840105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002425827,0.000005098848,0.0002660323,0.00000716244,0.000001947448,0.0001133792,0.000004219908,0.00006151133,0.9988229,0.0001108436,0.00001739412,0.000565279],"study_design_scores_gemma":[0.00001110467,0.00008708441,0.013924,0.000004299549,0.00001065032,0.001512041,0.00002320315,0.001711971,0.9799349,0.0002097895,0.002567599,0.000003348985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960394,0.0004790917,0.002040053,0.0000516826,0.00001010447,0.000008159614,0.0001352142,0.00007205942,0.001164216],"genre_scores_gemma":[0.9977888,0.0001935915,0.0007854272,0.000008650773,0.000004604462,0.00000667507,0.000214274,0.000008707096,0.0009891805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005996116,"threshold_uncertainty_score":0.002005935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0330945555041379,"score_gpt":0.2687944799375803,"score_spread":0.2356999244334424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}