{"id":"W1969271703","doi":"10.1056/nejmoa1407309","title":"Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B","year":2014,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1250,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Medical Research Council; University College London Hospitals NHS Foundation Trust; National Institute for Health and Care Research; American Lebanese Syrian Associated Charities; Assisi Foundation of Memphis; NHS Blood and Transplant; University College London; Howard Hughes Medical Institute","keywords":"Factor IX; Medicine; Genetic enhancement; Internal medicine; Gastroenterology; Toxicity; Adverse effect; Surgery; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009198183,0.0002042614,0.0004030902,0.0001212765,0.0001311761,0.000352187,0.0001696261,0.00032875,0.0006595439],"category_scores_gemma":[0.00133279,0.00006058094,0.0002162082,0.0001236469,0.0002785284,0.000228427,0.0001124638,0.0005957499,0.0001517638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002152349,"about_ca_system_score_gemma":0.0001562485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001639141,"about_ca_topic_score_gemma":0.00009771503,"domain_scores_codex":[0.9996859,0.0001440336,0.00002661204,0.00003411193,0.00007724965,0.00003224101],"domain_scores_gemma":[0.9990902,0.0002820215,0.0004024663,0.00004629583,0.00005828502,0.0001207532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06368142,0.005002687,0.1401742,0.0008058765,0.001108521,0.001204326,0.0003942289,0.004750766,0.238784,0.0005290806,0.002760923,0.540804],"study_design_scores_gemma":[0.01002139,0.3878864,0.4762246,0.000213315,0.001034951,0.0121046,0.000171623,0.007204744,0.09235942,0.0006403856,0.01207781,0.00006085702],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923468,0.006127153,0.0006216153,0.0001389837,0.000009189823,0.00002466039,0.00008415963,0.0000196371,0.0006277475],"genre_scores_gemma":[0.9987709,0.0006477181,0.0001390464,0.00006672506,0.00002566164,0.00001873866,0.0001859302,0.000003115037,0.0001421713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009198183,"threshold_uncertainty_score":0.004864514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03263389734612409,"score_gpt":0.3254365059104377,"score_spread":0.2928026085643136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}