{"id":"W1969315790","doi":"10.3390/molecules18011015","title":"Chitosan Rate of Uptake in HEK293 Cells is Influenced by Soluble versus Microparticle State and Enhanced by Serum-Induced Cell Metabolism and Lactate-Based Media Acidification","year":2013,"lang":"en","type":"article","venue":"Molecules","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chitosan; Chemistry; Microparticle; Solubility; Polysaccharide; Biophysics; Glucosamine; Biochemistry; Intracellular; Flow cytometry; Chromatography; Molecular biology; Chemical engineering; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000273959,0.0002326358,0.0002157354,0.00009913713,0.00007556806,0.0002750501,0.0001840983,0.0002231739,0.0006458794],"category_scores_gemma":[0.0003499832,0.0001000304,0.0002121243,0.0001214058,0.000152603,0.0001949612,0.000161071,0.0002403052,0.0001861537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004475589,"about_ca_system_score_gemma":0.0001957725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001250349,"about_ca_topic_score_gemma":0.001178352,"domain_scores_codex":[0.99981,0.00003479157,0.00002668885,0.00003710479,0.00006077307,0.00003055366],"domain_scores_gemma":[0.9997554,0.00009406621,0.00005086411,0.00002274298,0.00006286595,0.00001409568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001219256,0.00000873192,0.0004256541,0.00003450572,0.000004943119,0.00002651586,0.00001699882,0.00003726943,0.9983877,0.00001984521,0.00002016736,0.0008956728],"study_design_scores_gemma":[0.000004128171,0.00009294513,0.003465694,0.000002608394,0.000008105074,0.00006810707,0.00001058526,0.0005959623,0.995419,0.000006045768,0.0003240477,0.000002815603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930693,0.001565265,0.003841134,0.00008459021,0.00002118087,0.00003119858,0.0004390383,0.00006032115,0.0008879426],"genre_scores_gemma":[0.9954123,0.0005497872,0.002560198,0.00003817906,0.000005777275,0.00003338795,0.0003721453,0.00002009742,0.001008013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001250349,"threshold_uncertainty_score":0.003247261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00853274040308033,"score_gpt":0.2349575284770034,"score_spread":0.2264247880739231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}