{"id":"W1969315790","doi":"10.3390/molecules18011015","title":"Chitosan Rate of Uptake in HEK293 Cells is Influenced by Soluble versus Microparticle State and Enhanced by Serum-Induced Cell Metabolism and Lactate-Based Media Acidification","year":2013,"lang":"en","type":"article","venue":"Molecules","topic":"Skin and Cellular Biology Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Polytechnique Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chitosan; Chemistry; Microparticle; Solubility; Polysaccharide; Biophysics; Glucosamine; Biochemistry; Intracellular; Flow cytometry; Chromatography; Molecular biology; Chemical engineering; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001433344,0.0001598765,0.0001848032,0.00004521558,0.00004343092,0.00003132538,0.0001320009,0.0001368758,0.0000234806],"category_scores_gemma":[0.00003524215,0.0001506616,0.00003067959,0.00009383995,0.0001522687,0.00000877646,0.00007047458,0.00009578546,0.000008933661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003795801,"about_ca_system_score_gemma":0.00004505099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001617553,"about_ca_topic_score_gemma":0.00003211282,"domain_scores_codex":[0.9988697,0.0001370019,0.0002348905,0.0003736415,0.00008233446,0.0003024693],"domain_scores_gemma":[0.9994907,0.00003172705,0.00008652491,0.0002288482,0.00005153856,0.0001106455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001722331,0.0000646019,0.0003389376,0.00001964463,0.00001761647,8.252215e-7,0.000128734,0.000004202755,0.9975065,0.000001523158,0.0004145152,0.00133069],"study_design_scores_gemma":[0.002018143,0.0001546994,0.003513277,0.000005717356,0.000009594384,4.247661e-7,0.0001016177,0.0001501517,0.9935212,0.00001828365,0.0003493231,0.0001575705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974889,0.0017455,0.0001310509,0.0001607398,0.00005403738,0.0002614174,0.00005228556,0.000005149106,0.0001009557],"genre_scores_gemma":[0.9988766,0.0005078971,0.0002010737,0.000146175,0.000009475521,0.0000415217,0.00009767908,0.00001753936,0.000102029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985278,"threshold_uncertainty_score":0.6143799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00853274040308033,"score_gpt":0.2349575284770034,"score_spread":0.2264247880739231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}