{"id":"W1969320073","doi":"10.1038/nchembio.350","title":"A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor","year":2010,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research","keywords":"Streptomyces coelicolor; Histidine kinase; Vancomycin; Glycopeptide; Histidine; Kinase; Gene; Response regulator; Biology; Two-component regulatory system; Glycopeptide antibiotic; Function (biology); Microbiology; Chemistry; Biochemistry; Cell biology; Genetics; Staphylococcus aureus; Antibiotics; Bacterial protein; Amino acid; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001478974,0.000257539,0.0002149818,0.0002146531,0.0002624845,0.0004771003,0.0003911387,0.000804716,0.001705033],"category_scores_gemma":[0.0002116834,0.0002137086,0.0002140504,0.0001485135,0.0003355927,0.0002412399,0.0003756505,0.0006958834,0.000673246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008820049,"about_ca_system_score_gemma":0.0003318834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147574,"about_ca_topic_score_gemma":0.001602852,"domain_scores_codex":[0.9998528,0.00001691311,0.000003897081,0.00003630653,0.00003650007,0.00005354143],"domain_scores_gemma":[0.9999121,0.00002021279,0.00001391482,0.00000828671,0.00001139936,0.00003400848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004324475,0.000003944197,0.00006751106,0.000005832738,0.0000010339,0.0000286911,0.000003831709,0.00003047056,0.9990724,0.0001954129,0.00005684264,0.0004907718],"study_design_scores_gemma":[0.00001156179,0.00007017305,0.001163649,0.000003086843,0.000003829263,0.0003017916,0.00002467782,0.001155466,0.9952111,0.0001396896,0.001909563,0.000005580873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869235,0.000993196,0.007619232,0.0006515707,0.00008486935,0.00002081476,0.0002589642,0.0001224621,0.003325356],"genre_scores_gemma":[0.9920488,0.0003276636,0.003783159,0.0001521262,0.00001035801,0.000009918928,0.0003318464,0.00002879887,0.00330733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001705033,"threshold_uncertainty_score":0.006399393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005940356937280684,"score_gpt":0.2628585894359245,"score_spread":0.2569182324986438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}