{"id":"W1969345055","doi":"10.1038/sj.onc.1205190","title":"Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Karl und Veronica Carstens-Stiftung; Semmelweis Egyetem; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Hyperforin; Apoptosis; Biology; Hypericum perforatum; Caspase; Programmed cell death; Pharmacology; Gambogic acid; Vacuolization; Mitochondrial permeability transition pore; In vivo; Mitochondrion; Biochemistry; Cell biology; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000700485,0.0003416471,0.0001684531,0.0002564995,0.0001375452,0.0001568826,0.0001598938,0.0002048701,0.0009062708],"category_scores_gemma":[0.00006869628,0.00006483214,0.000171252,0.000136303,0.0002393982,0.0002339568,0.000107131,0.0005418987,0.0001360194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000330734,"about_ca_system_score_gemma":0.0002665455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009654863,"about_ca_topic_score_gemma":0.001854343,"domain_scores_codex":[0.999951,0.000006040968,0.000002653033,0.000007382191,0.00001424996,0.00001864458],"domain_scores_gemma":[0.9999551,0.00001210805,0.00001395044,0.000004018815,0.000004815013,0.00001006833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004124317,0.00009732178,0.0001083198,0.00009163388,0.000007014255,0.00009509715,0.00002392016,0.000105526,0.9906844,0.000315138,0.0001469023,0.007912341],"study_design_scores_gemma":[0.0000749309,0.0016016,0.002146652,0.000006225354,0.00001055314,0.0003597378,0.00001327307,0.000269505,0.9922664,0.0000658084,0.003182031,0.000003395439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838312,0.009746046,0.001314969,0.0002612115,0.00005765883,0.0000513679,0.0001979715,0.0000683549,0.004471255],"genre_scores_gemma":[0.9900815,0.005795416,0.0006866319,0.00004588438,0.00002850189,0.00002311188,0.0002691274,0.000008980275,0.003060884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009654863,"threshold_uncertainty_score":0.003031731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869782823096335,"score_gpt":0.2232961153612665,"score_spread":0.1945982871303031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}