{"id":"W1969345055","doi":"10.1038/sj.onc.1205190","title":"Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis","year":2002,"lang":"en","type":"article","venue":"Oncogene","topic":"Natural Compound Pharmacology Studies","field":"Agricultural and Biological Sciences","cited_by":263,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Karl und Veronica Carstens-Stiftung; Semmelweis Egyetem; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Hyperforin; Apoptosis; Biology; Hypericum perforatum; Caspase; Programmed cell death; Pharmacology; Gambogic acid; Vacuolization; Mitochondrial permeability transition pore; In vivo; Mitochondrion; Biochemistry; Cell biology; Endocrinology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000941965,0.0001427099,0.0002510452,0.00001351257,0.000102561,0.00000882588,0.0001320257,0.00007768652,0.0003982871],"category_scores_gemma":[0.00001372529,0.00006440812,0.00007555643,0.0002747888,0.0001012633,0.0001384352,0.00007037516,0.0001362658,0.000007851509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003718015,"about_ca_system_score_gemma":0.000003104487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007209833,"about_ca_topic_score_gemma":0.00005846841,"domain_scores_codex":[0.999066,0.00004611241,0.0002130975,0.0002521785,0.0002338437,0.0001887843],"domain_scores_gemma":[0.9994718,0.000125501,0.0002080562,0.00003758097,0.0001013963,0.00005567911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002637365,0.0002556125,0.005143293,0.000007590937,0.00002888675,2.497652e-7,0.00005683063,4.990757e-7,0.963186,0.000001806274,0.02932745,0.001965413],"study_design_scores_gemma":[0.0003184507,0.0001196617,0.008846091,0.00001743058,0.00004577416,5.825842e-7,0.0001330821,0.00001066757,0.9861207,0.00003996409,0.004213561,0.000134039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957325,0.001479815,0.000001483166,0.001123123,0.0002275788,0.0001433386,0.0004873005,0.00002215393,0.000782726],"genre_scores_gemma":[0.9983695,0.0008262257,0.00009082948,0.0001564579,0.0001590359,0.0000106901,0.0001188472,0.000001543157,0.0002668677],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02511389,"threshold_uncertainty_score":0.4360964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869782823096335,"score_gpt":0.2232961153612665,"score_spread":0.1945982871303031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}