{"id":"W1969367341","doi":"10.4161/cbt.3.11.1309","title":"siRNAs: Mechanism of RNA interference, In vivo and potential clinical applications","year":2004,"lang":"en","type":"review","venue":"Cancer Biology & Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Simon Fraser University","keywords":"RNA interference; Small interfering RNA; Gene silencing; Trans-acting siRNA; Functional genomics; RNA silencing; Computational biology; RNA; Biology; RNA-induced transcriptional silencing; DNA-directed RNA interference; RNA-induced silencing complex; microRNA; Cell biology; Genetics; Gene; Genomics; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005134,0.0007870492,0.000856426,0.001285897,0.0001965517,0.0008144854,0.0006098959,0.001244216,0.002202364],"category_scores_gemma":[0.0002703358,0.0002196076,0.0002660253,0.0007976822,0.0004324853,0.0007547134,0.0003032231,0.000899737,0.002860016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007384683,"about_ca_system_score_gemma":0.0006488829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004812665,"about_ca_topic_score_gemma":0.0006686586,"domain_scores_codex":[0.9998407,0.00003013821,0.00001887653,0.00002850869,0.00006770378,0.00001404426],"domain_scores_gemma":[0.9998883,0.00003711704,0.00001691278,0.000005074215,0.00003913214,0.00001348677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001014085,0.00008437557,0.0002348209,0.004489593,0.00002617076,0.0006504389,0.00007929769,0.000587536,0.03796593,0.008986006,0.01106042,0.935734],"study_design_scores_gemma":[0.00002046297,0.0002491176,0.0007456583,0.0006243115,0.00004531654,0.005232922,0.00004554696,0.0002258979,0.01574973,0.003221605,0.9738199,0.00001964848],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006535751,0.9914817,0.002365392,0.0004452403,0.0002052789,0.00001560027,0.00002957445,0.00003209575,0.004771556],"genre_scores_gemma":[0.00501749,0.9856976,0.00227614,0.0004028013,0.0002557334,0.00003860249,0.00005467559,0.000007119425,0.006249752],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002202364,"threshold_uncertainty_score":0.007367611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936837489902211,"score_gpt":0.387817453968767,"score_spread":0.3384490790697449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}