{"id":"W1969367341","doi":"10.4161/cbt.3.11.1309","title":"siRNAs: Mechanism of RNA interference, In vivo and potential clinical applications","year":2004,"lang":"en","type":"review","venue":"Cancer Biology & Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Simon Fraser University","keywords":"RNA interference; Small interfering RNA; Gene silencing; Trans-acting siRNA; Functional genomics; RNA silencing; Computational biology; RNA; Biology; RNA-induced transcriptional silencing; DNA-directed RNA interference; RNA-induced silencing complex; microRNA; Cell biology; Genetics; Gene; Genomics; Genome","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017317,0.0002994791,0.0009254478,0.0001097001,0.0000268341,0.000007926431,0.0003954292,0.0007558386,0.00006626363],"category_scores_gemma":[0.000008412148,0.0002376254,0.0003003167,0.0001059116,0.0002646789,0.000002444711,0.0001169552,0.0002515396,0.00000442748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002505927,"about_ca_system_score_gemma":0.0004001517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006326003,"about_ca_topic_score_gemma":0.00004144232,"domain_scores_codex":[0.9983022,0.0001708862,0.0006748453,0.0005937559,0.00003600026,0.0002223231],"domain_scores_gemma":[0.9991251,0.00002213856,0.0003344669,0.0003874873,0.00007101503,0.00005980399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006859598,0.00007892647,0.00005632184,0.000502034,0.0003361712,0.000001642228,0.00001557657,8.816955e-7,0.00870032,0.0005629753,0.00009444832,0.9895821],"study_design_scores_gemma":[0.001014369,0.001135443,0.00001611534,0.002088983,0.0001514208,0.0000213097,0.00002353682,9.738372e-7,0.004985101,0.002232445,0.9878173,0.0005129389],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004090703,0.9932255,0.001491755,0.00001761183,0.0003317047,0.0005804474,0.0001599835,0.000006195457,0.00009613145],"genre_scores_gemma":[0.01101607,0.987718,0.00009973547,0.0001318411,0.0003489913,0.0004009654,0.0001258744,0.00002691292,0.0001315378],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9890692,"threshold_uncertainty_score":0.9690083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04936837489902211,"score_gpt":0.387817453968767,"score_spread":0.3384490790697449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}