{"id":"W1969377459","doi":"10.1038/nchembio.1524","title":"Designed abscisic acid analogs as antagonists of PYL-PP2C receptor interactions","year":2014,"lang":"en","type":"article","venue":"Nature Chemical Biology","topic":"Plant Stress Responses and Tolerance","field":"Agricultural and Biological Sciences","cited_by":109,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Abscisic acid; Receptor; Chemistry; Biochemistry; Phosphatase; Arabidopsis; Biophysics; Stereochemistry; Biology; Phosphorylation; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003344909,0.000445368,0.0005016297,0.000180923,0.0003430935,0.000383567,0.0006190965,0.0003949947,0.004070111],"category_scores_gemma":[0.0002676338,0.0003041591,0.0002436971,0.0001655272,0.0002506146,0.0002809562,0.0002412466,0.00115041,0.0008628807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004884502,"about_ca_system_score_gemma":0.0003141503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004060844,"about_ca_topic_score_gemma":0.001388974,"domain_scores_codex":[0.9998103,0.00005193827,0.0000211493,0.00003822631,0.00003570118,0.00004272285],"domain_scores_gemma":[0.9998946,0.00002479566,0.00002230279,0.00001358708,0.00001583491,0.00002887291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007307823,0.0001278113,0.0001071945,0.0001020292,0.00002736725,0.0001369062,0.00002529653,0.0006304278,0.9938991,0.0006620166,0.0002487371,0.003302275],"study_design_scores_gemma":[0.0004276956,0.00145636,0.0004700597,0.00001161198,0.00005537915,0.0002821011,0.00002288607,0.001964909,0.9872553,0.0001246124,0.007906579,0.00002240714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747148,0.002845846,0.01246198,0.0003594336,0.0002957689,0.0005561516,0.0007835414,0.0003058776,0.007676606],"genre_scores_gemma":[0.9747711,0.002189392,0.01330352,0.000395725,0.00005265199,0.0002860836,0.001019458,0.0000612935,0.007920819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004070111,"threshold_uncertainty_score":0.01361585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008637830552251468,"score_gpt":0.2540515892081787,"score_spread":0.2454137586559272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}