{"id":"W1969379388","doi":"10.1016/j.jmb.2008.08.081","title":"Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export","year":2008,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; McMaster University","funders":"Luonnontieteiden ja Tekniikan Tutkimuksen Toimikunta; Canadian Institutes of Health Research; McMaster University","keywords":"Actinorhodin; TetR; Biology; Repressor; Regulator; Ligand (biochemistry); Biochemistry; Gene; Transcription factor; Receptor; Polyketide; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851763,0.000291184,0.0003506592,0.0001423889,0.0002815191,0.0006130721,0.0002981497,0.0004345122,0.002132004],"category_scores_gemma":[0.0002637065,0.0001851745,0.0002776744,0.00009448351,0.0003156051,0.000340605,0.0003819456,0.0007101961,0.00125698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000765425,"about_ca_system_score_gemma":0.0002903939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006241823,"about_ca_topic_score_gemma":0.001207764,"domain_scores_codex":[0.9998136,0.00003213504,0.00001078193,0.00004549682,0.00005087017,0.00004709929],"domain_scores_gemma":[0.999796,0.0000359933,0.00004296735,0.00002002882,0.00002204183,0.00008296419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001591176,0.000008895025,0.0001954073,0.00001367049,0.000001996667,0.00009042045,0.000009730454,0.00004222358,0.9983124,0.0001719778,0.0001663114,0.0008278477],"study_design_scores_gemma":[0.00004958607,0.0001199989,0.006450629,0.000008231465,0.000007715722,0.0005258527,0.0001013163,0.003948798,0.9854092,0.0001781212,0.003184576,0.00001597569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843683,0.001084063,0.008197702,0.0005454664,0.0001050592,0.00003088835,0.0004477222,0.0004820668,0.004738818],"genre_scores_gemma":[0.9886385,0.0002792054,0.003832325,0.0002107159,0.00002688942,0.00001911583,0.0009514036,0.00009359239,0.005948334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002132004,"threshold_uncertainty_score":0.007132232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01825399601694185,"score_gpt":0.261905763032501,"score_spread":0.2436517670155591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}