{"id":"W1969381321","doi":"10.1016/j.nano.2012.11.006","title":"Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA","year":2012,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Encana (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; HeLa; Endocytosis; Chemistry; In vitro; Intracellular; Transfection; Small molecule; Biochemistry; RNA interference; Cell biology; Cell; Biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004109482,0.0001886805,0.0004671529,0.0002001927,0.00006399355,6.521363e-7,0.0001885941,0.0005079117,0.00002407666],"category_scores_gemma":[0.0003738262,0.0001464663,0.00006804003,0.0001743311,0.000892796,0.000006982079,0.00009721983,0.0001160879,0.000001117975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007437875,"about_ca_system_score_gemma":0.0000492634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002252056,"about_ca_topic_score_gemma":0.00001121134,"domain_scores_codex":[0.9987482,0.00002215994,0.0005162477,0.0002772736,0.00005910172,0.0003770125],"domain_scores_gemma":[0.9990345,0.00008245814,0.0002521204,0.0003186096,0.0002164175,0.000095888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606081,0.00009706682,0.005458448,0.00006407334,0.00009947628,2.9814e-7,0.0001592324,8.423073e-7,0.9857037,0.002126819,0.0002121104,0.005817341],"study_design_scores_gemma":[0.001909569,0.003440734,0.000716963,0.00007990048,0.00009858629,0.00001910171,0.0002428828,0.00002396671,0.9902734,0.0004682194,0.002594802,0.0001318654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800313,0.009163305,0.009204556,0.0007983192,0.0003178217,0.0003216389,0.00002009659,0.0000171197,0.0001258611],"genre_scores_gemma":[0.9966964,0.00176217,0.0006490003,0.0002596632,0.0003239616,0.00004622559,0.000120492,0.00001489159,0.0001272419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01666507,"threshold_uncertainty_score":0.5972723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711638997265803,"score_gpt":0.2713503745503057,"score_spread":0.2542339845776477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}