{"id":"W1969381321","doi":"10.1016/j.nano.2012.11.006","title":"Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA","year":2012,"lang":"en","type":"article","venue":"Nanomedicine Nanotechnology Biology and Medicine","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Encana (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; HeLa; Endocytosis; Chemistry; In vitro; Intracellular; Transfection; Small molecule; Biochemistry; RNA interference; Cell biology; Cell; Biology; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857927,0.00027258,0.0001523489,0.0001578036,0.0001589005,0.0002901304,0.0001771604,0.0002819394,0.00126043],"category_scores_gemma":[0.00017016,0.0001324046,0.0001219946,0.00008302292,0.0001642758,0.0001946778,0.0002317525,0.0003034536,0.00057349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004009735,"about_ca_system_score_gemma":0.000225501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004236852,"about_ca_topic_score_gemma":0.0006170798,"domain_scores_codex":[0.9999219,0.00001628979,0.000005976374,0.00001603989,0.00002249449,0.00001731523],"domain_scores_gemma":[0.9999468,0.00001379086,0.00001509075,0.000003032812,0.00001160896,0.000009681898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004583307,0.000008058053,0.00001757292,0.00003355829,0.000001841435,0.00002999377,0.00001762507,0.0001073694,0.9972016,0.0003381246,0.00006282454,0.002135655],"study_design_scores_gemma":[0.000008134974,0.00004391858,0.00006833034,0.000002144035,0.00000313245,0.00003817779,0.000004368784,0.0006492335,0.9976866,0.00002248693,0.0014713,0.000002202037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9485281,0.002823077,0.0421955,0.0003866642,0.00007397513,0.0001278287,0.0001831711,0.0003586225,0.005323206],"genre_scores_gemma":[0.9759945,0.001083569,0.01239358,0.0001548575,0.00001703744,0.0001144329,0.0001765629,0.00005987588,0.01000568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00126043,"threshold_uncertainty_score":0.004216552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01711638997265803,"score_gpt":0.2713503745503057,"score_spread":0.2542339845776477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}