{"id":"W1969412156","doi":"10.1016/j.tox.2010.08.015","title":"Functional analysis of six human aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines","year":2010,"lang":"en","type":"article","venue":"Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Dow Chemical Company","keywords":"Aryl hydrocarbon receptor; CYP1B1; Aryl hydrocarbon receptor nuclear translocator; Chromatin immunoprecipitation; Biology; Transcription factor; Chromatin; Reporter gene; Cell culture; Receptor; Gene; Cancer research; Molecular biology; Gene expression; Endocrinology; Genetics; Cytochrome P450; Promoter; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810554,0.0001886058,0.0001718419,0.0003240087,0.0001886265,0.0002770746,0.0001711595,0.0001684572,0.001267807],"category_scores_gemma":[0.0002626472,0.0001120145,0.0002950398,0.0003535245,0.0001759055,0.0001063855,0.0001265055,0.0002412197,0.0004146356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001983322,"about_ca_system_score_gemma":0.0001536623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00296373,"about_ca_topic_score_gemma":0.002683798,"domain_scores_codex":[0.99983,0.00003134365,0.0000216716,0.00003106831,0.00004788651,0.00003800449],"domain_scores_gemma":[0.9998285,0.00006001422,0.0000205894,0.00002886602,0.00004050813,0.00002153982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002260895,0.00001875455,0.001725556,0.00001710353,0.00001344663,0.00008123564,0.00003565511,0.00005156388,0.9968705,0.00007925747,0.00004112757,0.0008397324],"study_design_scores_gemma":[0.0000452681,0.0004567347,0.05080503,0.000006986827,0.0001298434,0.002634364,0.0002844643,0.001399489,0.9393601,0.00009842962,0.004766159,0.00001313204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967186,0.0005079011,0.00123953,0.00004742955,0.00001295832,0.00001270862,0.0009019275,0.00001923838,0.0005396367],"genre_scores_gemma":[0.9927275,0.000598591,0.00148469,0.00003671252,0.000005482044,0.00001909063,0.00350656,0.00002077835,0.001600667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00296373,"threshold_uncertainty_score":0.005892932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009589840134732243,"score_gpt":0.2473083615210422,"score_spread":0.2377185213863099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}