{"id":"W1969458729","doi":"10.1038/nsmb.1915","title":"Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Cancer Research Society; Rutgers Cancer Institute of New Jersey; Fonds Québécois de la Recherche sur la Nature et les Technologies; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Science Foundation","keywords":"RAD51; PALB2; Homologous recombination; BRCA2 Protein; Biology; DNA repair; Cell biology; Genetics; DNA; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002417534,0.0003840247,0.0002760047,0.0002571841,0.0002241634,0.0007135291,0.0003183854,0.000428805,0.001474935],"category_scores_gemma":[0.0004110131,0.0003116071,0.0001819113,0.0001788561,0.0003182316,0.0002859132,0.0006458841,0.000545155,0.0005714556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004938848,"about_ca_system_score_gemma":0.0001864612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004002317,"about_ca_topic_score_gemma":0.0005001532,"domain_scores_codex":[0.9998202,0.00003802402,0.000009371212,0.00003317766,0.00005251284,0.00004667641],"domain_scores_gemma":[0.999811,0.00006194229,0.00002228277,0.00003277695,0.00001240126,0.00005964042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006696288,0.00005245641,0.0002939732,0.0000443025,0.000007728014,0.0001091054,0.00001530175,0.0002131553,0.9966733,0.0002894078,0.0001849682,0.001446582],"study_design_scores_gemma":[0.00007856343,0.000143022,0.005266268,0.00000717304,0.0000122315,0.0003356798,0.00005891804,0.003595951,0.9874316,0.000171791,0.002890849,0.000007968581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928974,0.002059425,0.001549919,0.0003412025,0.00004639568,0.00001576011,0.0001693554,0.0001358099,0.002784739],"genre_scores_gemma":[0.9965868,0.0003532819,0.000869878,0.00006955305,0.0000111851,0.00001944292,0.0002577065,0.00003606892,0.00179621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001474935,"threshold_uncertainty_score":0.004934192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002412321065777173,"score_gpt":0.2766658136524542,"score_spread":0.274253492586677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}