{"id":"W1969458729","doi":"10.1038/nsmb.1915","title":"Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination","year":2010,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":299,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"Cancer Research Society; Rutgers Cancer Institute of New Jersey; Fonds Québécois de la Recherche sur la Nature et les Technologies; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Science Foundation","keywords":"RAD51; PALB2; Homologous recombination; BRCA2 Protein; Biology; DNA repair; Cell biology; Genetics; DNA; Mutation; Gene; Germline mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001550922,0.000187118,0.0002127026,0.00009008488,0.00004996345,0.00001169546,0.0001577259,0.0008076712,0.00003125184],"category_scores_gemma":[0.0001710661,0.0001658493,0.00005049541,0.0001355676,0.0001254825,0.000006983644,0.0001126323,0.0004952375,3.57961e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000160241,"about_ca_system_score_gemma":0.00006877655,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001089189,"about_ca_topic_score_gemma":0.000435499,"domain_scores_codex":[0.9988822,0.0001161095,0.0002531573,0.0004383829,0.00007466498,0.0002354926],"domain_scores_gemma":[0.9993905,0.00001020943,0.0001297305,0.0002441734,0.0001759201,0.00004948916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006907373,0.00001266478,0.007879707,0.00001681052,0.00002520519,0.000004416305,0.00002441205,0.00005444212,0.9799138,0.004386906,0.000007426545,0.007605174],"study_design_scores_gemma":[0.0009852684,0.0003587488,0.05500669,0.00001528466,0.00001587523,0.0001381022,0.00001266266,0.0006758874,0.9397156,0.002730461,0.00009940397,0.0002460431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977717,0.0004684624,0.000375109,0.0004096921,0.0004002397,0.0004415345,0.00005694916,0.00001404701,0.00006221406],"genre_scores_gemma":[0.996238,0.00002031905,0.003159837,0.0002349547,0.00008284561,0.00003904663,0.0001789893,0.00002009161,0.0000259363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04712699,"threshold_uncertainty_score":0.6763138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002412321065777173,"score_gpt":0.2766658136524542,"score_spread":0.274253492586677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}