{"id":"W1969472653","doi":"10.1016/j.semnephrol.2013.08.009","title":"Complement-Mediated Cellular Injury","year":2013,"lang":"en","type":"review","venue":"Seminars in Nephrology","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Complement system; Cell biology; Complement membrane attack complex; Inflammation; Classical complement pathway; Complement component 5; Mesangial cell; Endoplasmic reticulum; Biology; Kidney; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004880019,0.0008281692,0.002958286,0.0008044816,0.0001225,0.00002069768,0.001141732,0.001176577,0.01460484],"category_scores_gemma":[0.0001319943,0.0007448763,0.0004924717,0.0004688324,0.0004213082,0.00007041678,0.0006740314,0.0009692146,0.01295061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002642902,"about_ca_system_score_gemma":0.0002760715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001243829,"about_ca_topic_score_gemma":0.00004240044,"domain_scores_codex":[0.9945843,0.001618357,0.001634642,0.0009487714,0.00007342478,0.001140547],"domain_scores_gemma":[0.997122,0.0009817254,0.0007146334,0.001062724,0.00005799489,0.00006087616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004032804,0.0003405483,0.0001735051,0.00561095,0.001048655,0.00009227347,0.0001010104,2.066895e-7,0.0007722885,0.0005464607,0.3505638,0.64071],"study_design_scores_gemma":[0.0005612846,0.0002127895,0.000008341132,0.003996047,0.0004450131,0.00009134134,0.00005302467,6.281114e-7,0.00002156528,0.0001021535,0.9939226,0.000585203],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004091486,0.9936938,0.00000575935,0.0000481138,0.001694456,0.002555803,0.0006005971,0.0001483977,0.0008439319],"genre_scores_gemma":[0.000156226,0.9913381,0.00005248358,0.0002697956,0.000111138,0.001273755,0.00519402,0.0001000445,0.001504416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6433588,"threshold_uncertainty_score":0.9995002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0338275712030437,"score_gpt":0.3136627305899863,"score_spread":0.2798351593869426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}