{"id":"W1969480537","doi":"10.1095/biolreprod.108.070193","title":"The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1","year":2008,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Endocrinology; Internal medicine; Spermatogenesis; Gonadotropin; Hypothalamic–pituitary–gonadal axis; Luteinizing hormone; Sertoli cell; Sirtuin 1; Hypothalamus; Hormone; Genetics; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000211469,0.000583187,0.0003303983,0.0006112613,0.0002131069,0.0004409315,0.0004422545,0.0003811015,0.002603113],"category_scores_gemma":[0.000192584,0.0003710436,0.0003095539,0.0002057126,0.0006383343,0.0002113323,0.0003141524,0.0007431722,0.0006856237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004329252,"about_ca_system_score_gemma":0.0002781959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006377478,"about_ca_topic_score_gemma":0.001308048,"domain_scores_codex":[0.9997858,0.0000384817,0.00001363428,0.00005885311,0.00006143907,0.00004183233],"domain_scores_gemma":[0.9997495,0.00001967392,0.0001207259,0.00002423513,0.00001523118,0.00007059087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002419175,0.00002880673,0.0005328414,0.00004163161,0.00001434939,0.00008889181,0.00002790172,0.0001240772,0.9944443,0.000330552,0.0001800168,0.003944697],"study_design_scores_gemma":[0.0001785603,0.0006080563,0.02755987,0.00002961885,0.0001116051,0.0008331516,0.00007760677,0.002787251,0.9521267,0.000564992,0.01508884,0.00003375281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778556,0.004748914,0.01005847,0.0005698797,0.0001612269,0.00004346214,0.001661035,0.001344392,0.003557054],"genre_scores_gemma":[0.9859741,0.002304038,0.004210969,0.0001510689,0.000049764,0.00004793335,0.0007294688,0.0001979165,0.006334653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002603113,"threshold_uncertainty_score":0.008708298,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823047846129179,"score_gpt":0.2910655024498038,"score_spread":0.2628350239885121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}