{"id":"W1969480537","doi":"10.1095/biolreprod.108.070193","title":"The Histone Deacetylase SIRT1 Controls Male Fertility in Mice Through Regulation of Hypothalamic-Pituitary Gonadotropin Signaling1","year":2008,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Centre National de la Recherche Scientifique; Institut National de la Santé et de la Recherche Médicale","keywords":"Biology; Endocrinology; Internal medicine; Spermatogenesis; Gonadotropin; Hypothalamic–pituitary–gonadal axis; Luteinizing hormone; Sertoli cell; Sirtuin 1; Hypothalamus; Hormone; Genetics; Downregulation and upregulation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000659543,0.0001206325,0.0004178763,0.00007619711,0.00009430823,7.721891e-7,0.0000760152,0.0001507938,0.00003714821],"category_scores_gemma":[0.0007095293,0.00008008465,0.00009368977,0.0001908349,0.0007592122,0.00005246662,0.00002012704,0.0001922327,0.000002669775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008222881,"about_ca_system_score_gemma":0.00009213432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005568899,"about_ca_topic_score_gemma":0.00002728594,"domain_scores_codex":[0.9985391,0.0001686393,0.0005787371,0.0003851995,0.000147057,0.0001812819],"domain_scores_gemma":[0.998861,0.0001347047,0.0002745872,0.0004899734,0.0002099385,0.00002981294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001926146,0.0002831169,0.03604328,0.000086988,0.00007901499,0.000009058393,0.0003408256,0.00009449544,0.9479553,0.0002376551,0.0006237541,0.01232044],"study_design_scores_gemma":[0.0036271,0.001387717,0.5928859,0.0001205302,0.00008620354,0.000479243,0.0002308682,0.0003097921,0.3916782,0.0008903776,0.008173319,0.0001308131],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752623,0.02071406,0.0002887652,0.002410491,0.00048718,0.0004704276,0.000003902514,0.00001922713,0.0003436581],"genre_scores_gemma":[0.996061,0.001739276,0.001082271,0.00004864664,0.0003015499,0.00001545663,0.00003683004,0.00000973418,0.0007052688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5568426,"threshold_uncertainty_score":0.3265757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823047846129179,"score_gpt":0.2910655024498038,"score_spread":0.2628350239885121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}