{"id":"W1969509102","doi":"10.1021/ja804233g","title":"Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Peptide nucleic acid; Guanine; Nucleic acid; Oligonucleotide; Nucleobase; Fluorescence; Peptide; Combinatorial chemistry; Biochemistry; Nucleic acid thermodynamics; Stereochemistry; Nucleotide; DNA; Gene; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001101402,0.0001235559,0.0002242862,0.000008786529,0.00009999866,0.000008509092,0.0002224756,0.00004277176,0.00001214162],"category_scores_gemma":[0.0001531549,0.00008058269,0.0001074616,0.000134705,0.0005941003,0.00001340782,0.0000781883,0.0001549188,1.851302e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002682646,"about_ca_system_score_gemma":0.000124468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006009537,"about_ca_topic_score_gemma":5.382289e-7,"domain_scores_codex":[0.9992222,0.0000294688,0.0002363179,0.0001523308,0.0002165069,0.0001432019],"domain_scores_gemma":[0.9991453,0.00001421769,0.0003600578,0.0001581228,0.0002098673,0.0001124756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006615191,0.0000717923,0.0008252092,0.000012432,0.00007113789,0.000002690188,0.0002485901,0.00001644581,0.9954355,0.00000110055,0.00251439,0.0001391968],"study_design_scores_gemma":[0.0005139419,0.0004366183,0.001669012,0.00006429459,0.00003219294,0.0002951455,0.0004457147,0.00006843441,0.9960539,0.000002930033,0.0003030457,0.0001148194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992962,0.00009909819,0.0002655829,0.0002096092,0.00001141792,0.00006142998,0.00002997185,0.000004427685,0.00002227136],"genre_scores_gemma":[0.9837312,0.00006384574,0.01566887,0.0003522141,0.0001303108,0.000003150431,0.00001978472,0.00001497106,0.00001564398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01556498,"threshold_uncertainty_score":0.3286067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098514991380357,"score_gpt":0.2124270777594962,"score_spread":0.2014419278456926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}