{"id":"W1969509102","doi":"10.1021/ja804233g","title":"Fluorescence and Hybridization Properties of Peptide Nucleic Acid Containing a Substituted Phenylpyrrolocytosine Designed to Engage Guanine with an Additional H-Bond","year":2008,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Peptide nucleic acid; Guanine; Nucleic acid; Oligonucleotide; Nucleobase; Fluorescence; Peptide; Combinatorial chemistry; Biochemistry; Nucleic acid thermodynamics; Stereochemistry; Nucleotide; DNA; Gene; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002562223,0.0002653636,0.0001993516,0.0001164898,0.0001688932,0.0001830647,0.0001888347,0.0004505807,0.0007015908],"category_scores_gemma":[0.0004126634,0.0001412619,0.000129717,0.0001358762,0.0002908042,0.0001789653,0.0001417443,0.0003076897,0.0001542507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002864026,"about_ca_system_score_gemma":0.0001413353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147199,"about_ca_topic_score_gemma":0.0009429366,"domain_scores_codex":[0.9998494,0.00003148101,0.000004432429,0.00004146337,0.0000396111,0.00003362979],"domain_scores_gemma":[0.9997978,0.00008064272,0.00003267549,0.00001260374,0.00003795799,0.00003849281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004887646,0.00000779975,0.00008226978,0.00001490587,0.00000261933,0.00003037756,0.00003417096,0.000100947,0.9991702,0.00005873459,0.000008662849,0.0004406073],"study_design_scores_gemma":[0.000007149317,0.0002547318,0.001250666,0.000002830595,0.000009327474,0.0001121947,0.00002136736,0.001093974,0.9969206,0.00001764727,0.0003026793,0.000006975131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979653,0.0002632969,0.001136616,0.00002444332,0.000005003931,0.000004324908,0.00002887023,0.00001714078,0.0005550372],"genre_scores_gemma":[0.9974942,0.0001694666,0.001494108,0.00001361067,0.000002616727,0.000007628773,0.00006624723,0.000007028605,0.0007450781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147199,"threshold_uncertainty_score":0.002346992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098514991380357,"score_gpt":0.2124270777594962,"score_spread":0.2014419278456926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}