{"id":"W1969524738","doi":"10.1038/nrd4002","title":"Modulation of oxidative stress as an anticancer strategy","year":2013,"lang":"en","type":"review","venue":"Nature Reviews Drug Discovery","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3554,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Carcinogenesis; Reactive oxygen species; DNA damage; Cell biology; Cancer cell; Cancer research; Signal transduction; Biology; Hedgehog signaling pathway; Cancer; Chemistry; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005245293,0.001086385,0.001673276,0.001635077,0.0002788356,0.0009485391,0.001103734,0.001185207,0.002376164],"category_scores_gemma":[0.0004102043,0.000334473,0.0004549875,0.001562609,0.0006281883,0.001044407,0.000757443,0.002263187,0.001787035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006627909,"about_ca_system_score_gemma":0.0006496056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007823954,"about_ca_topic_score_gemma":0.001925825,"domain_scores_codex":[0.9998406,0.00002208968,0.00001335601,0.00002762469,0.00007266631,0.00002363273],"domain_scores_gemma":[0.9998062,0.00007207633,0.00002957792,0.000009969614,0.00005889923,0.00002330026],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001183318,0.0001297891,0.0001963152,0.008515188,0.0001141101,0.0002869346,0.00003403634,0.000620381,0.0114386,0.008143468,0.03652385,0.933879],"study_design_scores_gemma":[0.00003464134,0.0001151365,0.0005118456,0.0009839381,0.0001103259,0.0007167535,0.00002888949,0.0001817221,0.002922132,0.003482226,0.9908879,0.00002455535],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002094387,0.9971361,0.0005084457,0.0003840183,0.00031443,0.000007528367,0.00002188471,0.00001588126,0.001402311],"genre_scores_gemma":[0.001480406,0.9968617,0.0003278264,0.0002623521,0.0001858901,0.000009939106,0.00003396648,0.000001830696,0.0008360831],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002376164,"threshold_uncertainty_score":0.007949054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02333854500831486,"score_gpt":0.3495345269482038,"score_spread":0.326195981939889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}