{"id":"W1969546273","doi":"10.1021/jo800336k","title":"Synthetic Studies toward Halichlorine: Complex Azaspirocycle Formation with Use of an NBS-Promoted Semipinacol Reaction","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Stereocenter; Cyclobutanone; Ketone; Reagent; Decane; Combinatorial chemistry; Stereochemistry; Organic chemistry; Enantioselective synthesis; Ring (chemistry); Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003179295,0.0003217247,0.0002713201,0.000164989,0.0002773675,0.0003014694,0.0004005551,0.0002677497,0.001489672],"category_scores_gemma":[0.0002778367,0.0001467794,0.000165367,0.0001524318,0.0003278814,0.0002532341,0.0002688363,0.0004653126,0.0006525721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040747,"about_ca_system_score_gemma":0.0003879548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006560576,"about_ca_topic_score_gemma":0.001322544,"domain_scores_codex":[0.9998092,0.00004318631,0.00001773605,0.0000430541,0.0000519033,0.00003493097],"domain_scores_gemma":[0.999859,0.00002948409,0.0000341728,0.00002263558,0.00002311919,0.00003153958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001229507,0.00004058598,0.0001255191,0.00009648465,0.000006822477,0.0002578183,0.0001030568,0.000396505,0.9951335,0.0006275616,0.00004543521,0.003043704],"study_design_scores_gemma":[0.00002223665,0.0003271406,0.0002671348,0.000003692237,0.000005853626,0.0001967746,0.00002303974,0.0003582701,0.9967698,0.00003779971,0.00198163,0.000006665577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843786,0.0004596583,0.006496468,0.00009315696,0.00001684166,0.0002030463,0.0002493687,0.0001097973,0.007992941],"genre_scores_gemma":[0.9903101,0.0004530161,0.00713085,0.00002559419,0.000006266889,0.00005725083,0.0002182324,0.00001977706,0.00177879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001489672,"threshold_uncertainty_score":0.004983425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1038354340189973,"score_gpt":0.3037541160582563,"score_spread":0.1999186820392589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}