{"id":"W1969551758","doi":"10.1016/j.bmc.2009.01.022","title":"Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins","year":2009,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":192,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Chicoutimi","funders":"Fonds Québécois de la Recherche sur la Nature et les Technologies","keywords":"Haemolysis; Chemistry; Oleanane; Cytotoxicity; Glycoside; Cytotoxic T cell; Cell culture; Biochemistry; Pharmacology; Stereochemistry; Triterpene; Biology; In vitro; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000169961,0.0002337206,0.000290063,0.00002539608,0.00008857765,0.00001818042,0.0001050621,0.0002190935,0.00002641554],"category_scores_gemma":[0.0002323792,0.0002015056,0.00003588889,0.00009930776,0.0003074236,0.0000111291,0.0000888295,0.0001789819,3.220228e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001911174,"about_ca_system_score_gemma":0.00006282656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002393396,"about_ca_topic_score_gemma":0.000003998759,"domain_scores_codex":[0.998889,0.00003485971,0.000189987,0.0004789837,0.0001799232,0.0002272714],"domain_scores_gemma":[0.9993725,0.00003739014,0.0001211913,0.0002669281,0.00006912014,0.0001328734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001501843,0.00005504568,0.0004883166,0.0002354628,0.00002137168,0.000003957337,0.00007134489,2.544278e-7,0.9957784,0.000003071199,0.00006785541,0.003124679],"study_design_scores_gemma":[0.0004485884,0.0002293151,0.005943974,0.00005800216,0.00007158681,0.000207344,0.0001930124,0.0001027296,0.9923121,0.00002473501,0.0001888589,0.0002197661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926726,0.006280043,0.00001005126,0.0005789876,0.00005295638,0.0001311399,0.00001180259,0.00001345305,0.0002489148],"genre_scores_gemma":[0.9975671,0.001604665,0.00006049461,0.000109009,0.0001728075,0.000001146847,0.00002355497,0.00001649024,0.0004447373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005455657,"threshold_uncertainty_score":0.821716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006001426603789277,"score_gpt":0.2164747532157716,"score_spread":0.2104733266119823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}