{"id":"W1969556083","doi":"10.1021/jm300215x","title":"Discovery of a Potent and Selective GPR120 Agonist","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"GPR120; Free fatty acid receptor 1; Chemistry; Agonist; Receptor; Pharmacology; Diabetes mellitus; Biochemistry; G protein-coupled receptor; Endocrinology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705939,0.0003819047,0.0003861208,0.0003967109,0.0002450536,0.0003422962,0.0004073768,0.0004222326,0.002635238],"category_scores_gemma":[0.00023565,0.0002233823,0.0002993862,0.0002487698,0.0001973684,0.000345483,0.0006358645,0.0008307529,0.001129307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002444017,"about_ca_system_score_gemma":0.0002808116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002519519,"about_ca_topic_score_gemma":0.0005832462,"domain_scores_codex":[0.9998698,0.00002342891,0.00000684466,0.0000220953,0.00002556447,0.00005234295],"domain_scores_gemma":[0.9999567,0.000005282187,0.000006104959,0.000003826983,0.00001015728,0.00001800681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006587175,0.0004528996,0.0003154675,0.0003406231,0.00003679438,0.0006598266,0.0001467965,0.001111726,0.9206078,0.002989166,0.003104225,0.069576],"study_design_scores_gemma":[0.001116444,0.01128134,0.003890608,0.0001328558,0.000169793,0.004533057,0.0001548093,0.004615354,0.8740098,0.001591824,0.0984055,0.00009858641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9127205,0.01477835,0.03848442,0.002848862,0.0003169381,0.0008272477,0.002198281,0.0005931399,0.02723233],"genre_scores_gemma":[0.955814,0.01244811,0.01722354,0.001319165,0.0001117687,0.0002918702,0.002019624,0.00003894899,0.0107329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002635238,"threshold_uncertainty_score":0.008815765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006733846896537571,"score_gpt":0.2358746493533729,"score_spread":0.2291408024568353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}