{"id":"W1969556083","doi":"10.1021/jm300215x","title":"Discovery of a Potent and Selective GPR120 Agonist","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"GPR120; Free fatty acid receptor 1; Chemistry; Agonist; Receptor; Pharmacology; Diabetes mellitus; Biochemistry; G protein-coupled receptor; Endocrinology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000378593,0.00009545446,0.0001944959,0.0000162694,0.00002773904,0.000007804248,0.00009143793,0.00009604014,0.00001668513],"category_scores_gemma":[0.0001133055,0.0000725136,0.00008821525,0.00003750826,0.00006994823,0.00001002593,0.00003721028,0.000146257,1.823924e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001480374,"about_ca_system_score_gemma":0.00007984085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003147485,"about_ca_topic_score_gemma":1.642047e-7,"domain_scores_codex":[0.9992641,0.00001851213,0.0002794238,0.00007959923,0.0002059518,0.0001523922],"domain_scores_gemma":[0.9993806,0.00001370375,0.0002897608,0.00008186328,0.000118027,0.0001159757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001392511,0.00005724979,0.002162019,0.00005954392,0.00007368923,0.000004069906,0.0000934979,0.000002295434,0.9958202,0.00001075718,0.0004914791,0.001085925],"study_design_scores_gemma":[0.0004661965,0.0002446178,0.001015577,0.00007278071,0.00005516517,0.0004908536,0.0004269504,0.000003202246,0.9956846,0.00004643697,0.001418106,0.00007553268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918156,0.005145803,0.001821849,0.00007690965,0.0001441088,0.00002556253,0.000003523177,9.420091e-7,0.0009656987],"genre_scores_gemma":[0.9979482,0.0003604615,0.00049646,0.00005225947,0.0009165487,6.644333e-7,0.000004154458,0.000008932493,0.0002123003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006132616,"threshold_uncertainty_score":0.2957019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006733846896537571,"score_gpt":0.2358746493533729,"score_spread":0.2291408024568353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}