{"id":"W1969556651","doi":"10.1371/journal.pone.0095281","title":"A Novel Formulation of Tigecycline Has Enhanced Stability and Sustained Antibacterial and Antileukemic Activity","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institutes of Health; Stem Cell Network; National Cancer Institute; Princess Margaret Hospital Foundation; Leukemia and Lymphoma Society","keywords":"Tigecycline; In vivo; Pharmacology; Antimicrobial; Medicine; Antibiotics; Drug; Ascorbic acid; Chemistry; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001087468,0.0003797522,0.0002580775,0.0002849849,0.0001720716,0.0002873799,0.0002794631,0.0004225037,0.0007919978],"category_scores_gemma":[0.0001644477,0.00009472483,0.0002004788,0.0001762944,0.0001774843,0.0003467719,0.0001415226,0.0004970469,0.0001513949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004705135,"about_ca_system_score_gemma":0.0002505186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007793483,"about_ca_topic_score_gemma":0.001226061,"domain_scores_codex":[0.9998809,0.00001243714,0.000009432638,0.00003113021,0.00004639968,0.00001967936],"domain_scores_gemma":[0.9999217,0.000008925292,0.00003110634,0.000003317247,0.00001656684,0.00001839052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005551982,0.00004180011,0.00004370645,0.00005593371,0.000003750722,0.00004883322,0.000008363849,0.00007221282,0.9953811,0.00005134602,0.00003125505,0.004206208],"study_design_scores_gemma":[0.00004422694,0.001168638,0.001705367,0.00001182676,0.00002810649,0.0003856283,0.00001657811,0.001077569,0.9896117,0.00001842168,0.005920201,0.00001174083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781002,0.00633697,0.0124349,0.0001891651,0.00009840571,0.0002192672,0.000182665,0.0001263682,0.002312038],"genre_scores_gemma":[0.9715299,0.002829668,0.02230609,0.0001034042,0.00004141838,0.00009901964,0.0001981754,0.0000351801,0.002857033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007919978,"threshold_uncertainty_score":0.003413856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02517758778227007,"score_gpt":0.2331075610465203,"score_spread":0.2079299732642503,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}