{"id":"W1969589045","doi":"10.1371/journal.pone.0054605","title":"Alterations in Gene Expression in Mutant Amyloid Precursor Protein Transgenic Mice Lacking Niemann-Pick Type C1 Protein","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Innovates; University of Sydney; National Institute on Aging; University of Alberta; Alberta Innovates - Health Solutions","keywords":"NPC1; Niemann–Pick disease, type C; Biology; Amyloid precursor protein; Gliosis; Null allele; Transgene; Genetically modified mouse; Niemann–Pick disease; Wild type; Gene expression; Neurodegeneration; Alzheimer's disease; Endocrinology; Gene; Internal medicine; Mutant; Cell biology; Genetics; Cholesterol; Medicine; Neuroscience; Disease; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001343506,0.0006427379,0.0003666247,0.0009475685,0.0002248531,0.0003949295,0.0002569393,0.0004825481,0.001099],"category_scores_gemma":[0.0001782438,0.0003713295,0.0003435044,0.0004008027,0.0004065277,0.0001921243,0.0002044786,0.0007186212,0.0003470072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003207646,"about_ca_system_score_gemma":0.0002363593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034157,"about_ca_topic_score_gemma":0.001132314,"domain_scores_codex":[0.9997197,0.00001859368,0.00003177909,0.0001087999,0.00006849715,0.00005260871],"domain_scores_gemma":[0.9995773,0.00004994691,0.0001608342,0.00002949156,0.00003855536,0.0001437018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001985143,0.00003343705,0.000190068,0.00001830831,0.000007320094,0.00008957121,0.00001911322,0.0000412461,0.9989392,0.00005568912,0.00002530866,0.0003823172],"study_design_scores_gemma":[0.0001230342,0.0007534524,0.04000159,0.00002702963,0.0001080892,0.001335338,0.0001144493,0.002017474,0.9523765,0.0002998156,0.002807216,0.00003587449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940696,0.0006572995,0.002289757,0.00008279955,0.000033452,0.00003654571,0.00200739,0.0001793392,0.0006439564],"genre_scores_gemma":[0.9836586,0.001696805,0.00597061,0.0001567561,0.00002099545,0.0002042899,0.002641117,0.0001478123,0.005502931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001099,"threshold_uncertainty_score":0.003676474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05280303714397573,"score_gpt":0.2793251776912698,"score_spread":0.2265221405472941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}