{"id":"W1969593814","doi":"10.1074/jbc.m112.393181","title":"Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Cytidine deaminase; APOBEC3G; Somatic hypermutation; Activation-induced (cytidine) deaminase; Deamination; Cytidine; DNA; Biology; Molecular biology; Chemistry; Genetics; Biochemistry; Enzyme; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001197273,0.0002072016,0.0001917029,0.0001320162,0.0001236367,0.0002457199,0.0001719846,0.0002360476,0.0005360293],"category_scores_gemma":[0.000215087,0.00009430861,0.0002294157,0.0001795403,0.0001066824,0.0001488924,0.0001203119,0.0003861033,0.0001987801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347988,"about_ca_system_score_gemma":0.0001711715,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002662213,"about_ca_topic_score_gemma":0.001831631,"domain_scores_codex":[0.999881,0.00002075789,0.000008294012,0.00002902917,0.00003976523,0.00002097092],"domain_scores_gemma":[0.9998393,0.00004337207,0.00003378661,0.00001539768,0.00004238562,0.00002567721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002606493,0.00001541665,0.0003673382,0.00002463808,0.000008329772,0.00001904029,0.00001041619,0.0002062013,0.9986947,0.00005394154,0.00001009432,0.0005638179],"study_design_scores_gemma":[0.000003901908,0.0001880342,0.006841196,0.0000043738,0.00001566555,0.0001612824,0.00003242878,0.004716243,0.9870136,0.00008264064,0.0009341639,0.000006534785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926431,0.001253397,0.004392083,0.00003712176,0.00001137907,0.00001771087,0.0004765204,0.00003131871,0.001137554],"genre_scores_gemma":[0.9955767,0.0005037298,0.002318217,0.00001617373,0.000002349979,0.00001368438,0.0006042386,0.00001001962,0.0009548898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002662213,"threshold_uncertainty_score":0.005293489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02183697120003276,"score_gpt":0.2785971473451801,"score_spread":0.2567601761451473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}