{"id":"W1969615465","doi":"10.1073/pnas.1006610107","title":"Metacaspase Yca1 is required for clearance of insoluble protein aggregates","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":170,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Saccharomyces cerevisiae; Cell biology; Biology; Proteases; Yeast; Proteasome; Caspase; Programmed cell death; Autolysis (biology); Apoptosis; Protein aggregation; Mutant; Catabolism; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011936,0.0005653196,0.0003019601,0.0003067129,0.0003520501,0.0006629043,0.0003232389,0.0002817452,0.001493491],"category_scores_gemma":[0.0003070222,0.0001956807,0.0002182664,0.0002097219,0.0002025521,0.0003279846,0.0004471882,0.0004751033,0.001213346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005537482,"about_ca_system_score_gemma":0.0004182902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001357837,"about_ca_topic_score_gemma":0.001847938,"domain_scores_codex":[0.9998522,0.00001278553,0.00001670289,0.00004057489,0.00005085041,0.0000268648],"domain_scores_gemma":[0.9996316,0.00003568006,0.0001146695,0.00004480146,0.00005166826,0.0001214735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014189,0.00001503351,0.0008941859,0.00003882742,0.000005999344,0.0001515542,0.00001113524,0.00004030819,0.9967111,0.0001171312,0.0001116237,0.001801647],"study_design_scores_gemma":[0.00001240479,0.00005796672,0.02587168,0.000009923388,0.00001716551,0.001285318,0.00004623789,0.001320574,0.9657865,0.0001305838,0.005452958,0.000008582999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877155,0.003292585,0.005116165,0.0002599515,0.00006049287,0.00002084068,0.00199944,0.0004527849,0.001082191],"genre_scores_gemma":[0.9897571,0.0006580385,0.003199286,0.00005010857,0.00001362997,0.00001870347,0.003109542,0.0001020967,0.003091433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493491,"threshold_uncertainty_score":0.004996181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04129310291694267,"score_gpt":0.3329621309616786,"score_spread":0.291669028044736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}