{"id":"W1969644356","doi":"10.1016/j.trim.2014.10.001","title":"De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed","year":2014,"lang":"en","type":"article","venue":"Transplant Immunology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Immunosuppression; Priming (agriculture); Calcineurin; Immunology; CD8; Population; Memory T cell; T cell; Biology; Transplantation; Immune system; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002363237,0.0004086156,0.0006695304,0.000194999,0.0001820124,0.0000191499,0.0002401461,0.0003678768,0.0003645101],"category_scores_gemma":[0.00001062591,0.0003331155,0.0003036821,0.0001271167,0.00008570214,0.0001267928,0.00002085904,0.0003864143,0.0002310444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123593,"about_ca_system_score_gemma":0.0001430529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002452864,"about_ca_topic_score_gemma":0.00002879119,"domain_scores_codex":[0.9978815,0.0001835161,0.0005015588,0.0004950484,0.0002690798,0.0006692744],"domain_scores_gemma":[0.9989594,0.0002487166,0.0001215307,0.0004391314,0.00007805038,0.000153165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004235455,0.0008257256,0.01081912,0.0003236688,0.005267442,0.001643258,0.01741228,0.00002702486,0.944102,0.0004954332,0.00007922424,0.01476939],"study_design_scores_gemma":[0.02963354,0.003064665,0.1080612,0.002039815,0.003493281,0.003395157,0.000666207,0.000245883,0.8347618,0.001087273,0.01205144,0.001499772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838935,0.001780959,0.005866212,0.001185451,0.0006227717,0.0005722535,0.0000983353,0.0001788091,0.005801778],"genre_scores_gemma":[0.9918671,0.002289332,0.003264377,0.0009784726,0.00005814592,0.00006368547,0.000387938,0.00006243199,0.001028471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1093402,"threshold_uncertainty_score":0.9999121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170097241701273,"score_gpt":0.2632176094487643,"score_spread":0.246207885278637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}