{"id":"W1969644356","doi":"10.1016/j.trim.2014.10.001","title":"De novo alloreactive memory CD8+ T cells develop following allogeneic challenge when CNI immunosuppression is delayed","year":2014,"lang":"en","type":"article","venue":"Transplant Immunology","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research","keywords":"Immunosuppression; Priming (agriculture); Calcineurin; Immunology; CD8; Population; Memory T cell; T cell; Biology; Transplantation; Immune system; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003524042,0.0003140713,0.0005679622,0.0002489297,0.000249046,0.0006152848,0.0003072157,0.0006260414,0.002557871],"category_scores_gemma":[0.0005803962,0.0001422706,0.0001748772,0.0001233254,0.0002769323,0.000556495,0.0002725693,0.002074131,0.0004423808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002645522,"about_ca_system_score_gemma":0.0003393424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003628231,"about_ca_topic_score_gemma":0.0009838936,"domain_scores_codex":[0.9997147,0.00003561904,0.00001746699,0.00004683816,0.0000703218,0.0001150689],"domain_scores_gemma":[0.9996018,0.0001013128,0.00008221251,0.00005628623,0.0000371557,0.0001212793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002619073,0.001045028,0.005544937,0.00009539126,0.00002367991,0.0008646161,0.0001342017,0.000196159,0.9780488,0.0005674902,0.0003754421,0.01048529],"study_design_scores_gemma":[0.000337672,0.01175507,0.1107864,0.00008219653,0.0001350814,0.005826707,0.0007375822,0.004744157,0.8549657,0.001356258,0.00922894,0.00004419163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950953,0.0003558259,0.0007645574,0.00008822832,0.0001378902,0.00006078139,0.00007846644,0.00004214474,0.003376894],"genre_scores_gemma":[0.9978843,0.0001009428,0.0004713302,0.00008376974,0.00005075884,0.00004013333,0.0001018066,0.00000852772,0.001258383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002557871,"threshold_uncertainty_score":0.008556962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0170097241701273,"score_gpt":0.2632176094487643,"score_spread":0.246207885278637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}