{"id":"W1969671007","doi":"10.1074/jbc.c200023200","title":"COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":412,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute","keywords":"Histone methyltransferase; Biology; Histone methylation; Histone code; Histone H3; Genetics; Histone; Chromatin; Histone octamer; Epigenetics; Bromodomain; EZH2; Nucleosome; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140304,0.000655557,0.0003127067,0.0004742915,0.0004310059,0.0004979795,0.0003463685,0.0003764828,0.00323576],"category_scores_gemma":[0.0001587697,0.0001947283,0.0003600658,0.0003246983,0.0002872583,0.0003389171,0.0005129075,0.0004477832,0.002471648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005713925,"about_ca_system_score_gemma":0.0004882584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001419866,"about_ca_topic_score_gemma":0.002348349,"domain_scores_codex":[0.9998724,0.000006221562,0.000006809156,0.00003346553,0.00006284921,0.00001818549],"domain_scores_gemma":[0.9999034,0.000004530323,0.00002855475,0.000008860159,0.00001461188,0.00003983771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001204575,0.0000146777,0.0009973542,0.0001642776,0.00001792909,0.0002668039,0.00002786894,0.00008314609,0.9793587,0.0003534336,0.0009145988,0.01768075],"study_design_scores_gemma":[0.00002380303,0.0002262219,0.02263577,0.0000307264,0.00005587745,0.003099518,0.00006833913,0.0005276185,0.8762451,0.0003938151,0.0966712,0.0000219094],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7968615,0.1275949,0.03381385,0.00126424,0.0009049022,0.0003770322,0.008592051,0.003223863,0.02736766],"genre_scores_gemma":[0.8929313,0.02317132,0.01559798,0.0003307622,0.0001356796,0.00008118919,0.01456983,0.0002048315,0.05297704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00323576,"threshold_uncertainty_score":0.01082468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02386816671650616,"score_gpt":0.2577416356559442,"score_spread":0.2338734689394381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}