{"id":"W1969682929","doi":"10.1016/j.lfs.2006.01.010","title":"Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart","year":2006,"lang":"en","type":"article","venue":"Life Sciences","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Centre for Addiction and Mental Health","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Rolipram; Chemistry; Pharmacology; Internal medicine; Endocrinology; Serotonin; Synaptic cleft; Reuptake; Neurotransmitter; Phosphodiesterase; Receptor; Biology; Medicine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003251186,0.0007708854,0.0007162443,0.0003661107,0.000321466,0.0004692249,0.0009310911,0.0005574907,0.004119122],"category_scores_gemma":[0.0005017335,0.0007015564,0.0005165209,0.0003014975,0.0005751394,0.0006076706,0.0003182507,0.001470025,0.0008360533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008550606,"about_ca_system_score_gemma":0.0005414893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003523653,"about_ca_topic_score_gemma":0.006046238,"domain_scores_codex":[0.9997277,0.00004768644,0.00001210007,0.00004052166,0.00002443898,0.0001475772],"domain_scores_gemma":[0.9994587,0.0002095428,0.00006260371,0.00007292918,0.00002812217,0.0001680816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004049676,0.000122008,0.0002876717,0.00009597889,0.00003326324,0.0001544016,0.00004880883,0.0001419062,0.9930734,0.0002380163,0.0001123811,0.001642494],"study_design_scores_gemma":[0.0001051957,0.001064596,0.004280983,0.000008190614,0.00005517064,0.0001529153,0.00004356676,0.0009625647,0.9928832,0.00004847585,0.0003878834,0.00000723241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942462,0.002274597,0.001095387,0.0001600959,0.00005353896,0.00002185356,0.0002549331,0.00008264171,0.001810675],"genre_scores_gemma":[0.993434,0.001376833,0.001140962,0.00006265478,0.00004966039,0.00003354888,0.000584459,0.00003163809,0.003286264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004119122,"threshold_uncertainty_score":0.01377988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006592859077862848,"score_gpt":0.2415656138542644,"score_spread":0.2349727547764016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}